Cited 5 times in
EFFICACY OF ADJUVANT TOPICAL DORZOLAMIDE-TIMOLOL IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION REFRACTORY TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY
DC Field | Value | Language |
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dc.contributor.author | 고형준 | - |
dc.contributor.author | 김성수 | - |
dc.contributor.author | 변석호 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 이승규 | - |
dc.contributor.author | 이지환 | - |
dc.date.accessioned | 2019-12-18T01:26:15Z | - |
dc.date.available | 2019-12-18T01:26:15Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0275-004X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173518 | - |
dc.description.abstract | PURPOSE: To evaluate the efficacy of adjuvant topical dorzolamide-timolol in patients with neovascular age-related macular degeneration unresponsive to anti-vascular endothelial growth factor therapy. METHODS: This retrospective, interventional study included 15 patients with neovascular age-related macular degeneration refractory to anti-vascular endothelial growth factor. Patients used topical dorzolamide-timolol twice daily in the neovascular age-related macular degeneration eye and received anti-vascular endothelial growth factor therapy at each visit, with the same fixed interval and agent as before the addition of dorzolamide-timolol. Central macular thickness, maximal subretinal fluid height, and maximal pigment epithelial detachment height were measured at baseline and every visit. RESULTS: The mean follow-up period was 17.2 ± 5.5 weeks. The mean central macular thickness decreased from 383.5 μm at baseline to 298.3 μm at the final visit (P = 0.041). The mean maximal subretinal fluid height decreased from 105.0 μm at baseline to 58.3 μm at the final visit (P = 0.021). Complete resolution of subretinal fluid was observed in 3 of 11 subretinal fluid-type eyes. There was no significant change in the maximal pigment epithelial detachment height. The mean logarithm of the minimum angle of resolution visual acuity decreased from 0.61 (20/81 Snellen) at baseline to 0.66 (20/91 Snellen) at final visit, which was not significant (P = 0.314). The mean intraocular pressure decreased significantly from 14.9 mmHg at baseline to 12.3 mmHg at the final visit (P = 0.005). CONCLUSION: The use of adjuvant topical dorzolamide-timolol was effective in decreasing central macular thickness and subretinal fluid in patients with neovascular age-related macular degeneration refractory to continual fixed-interval intravitreal anti-vascular endothelial growth factor therapy, but did not result in functional improvement in this short-term study. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | EFFICACY OF ADJUVANT TOPICAL DORZOLAMIDE-TIMOLOL IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION REFRACTORY TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Lee, Ji Hwan | - |
dc.contributor.googleauthor | Lee, Sung Chul | - |
dc.contributor.googleauthor | Byeon, Suk Ho | - |
dc.contributor.googleauthor | Koh, Hyoung Jun | - |
dc.contributor.googleauthor | Kim, Sung Soo | - |
dc.contributor.googleauthor | Lee, Christopher Seungkyu | - |
dc.identifier.doi | 10.1097/IAE.0000000000002293 | - |
dc.contributor.localId | A00152 | - |
dc.contributor.localId | A00571 | - |
dc.contributor.localId | A01849 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A02913 | - |
dc.contributor.localId | A03222 | - |
dc.relation.journalcode | J02621 | - |
dc.identifier.eissn | 1539-2864 | - |
dc.identifier.pmid | 30161096 | - |
dc.identifier.url | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-201910000-00014&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.contributor.affiliatedAuthor | 고형준 | - |
dc.contributor.affiliatedAuthor | 김성수 | - |
dc.contributor.affiliatedAuthor | 변석호 | - |
dc.contributor.affiliatedAuthor | 이성철 | - |
dc.contributor.affiliatedAuthor | 이승규 | - |
dc.contributor.affiliatedAuthor | 이지환 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1953 | - |
dc.citation.endPage | 1958 | - |
dc.identifier.bibliographicCitation | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol.39(10) : 1953-1958, 2019 | - |
dc.identifier.rimsid | 63713 | - |
dc.type.rims | ART | - |
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