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EFFICACY OF ADJUVANT TOPICAL DORZOLAMIDE-TIMOLOL IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION REFRACTORY TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY

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dc.contributor.author고형준-
dc.contributor.author김성수-
dc.contributor.author변석호-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author이지환-
dc.date.accessioned2019-12-18T01:26:15Z-
dc.date.available2019-12-18T01:26:15Z-
dc.date.issued2019-
dc.identifier.issn0275-004X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173518-
dc.description.abstractPURPOSE: To evaluate the efficacy of adjuvant topical dorzolamide-timolol in patients with neovascular age-related macular degeneration unresponsive to anti-vascular endothelial growth factor therapy. METHODS: This retrospective, interventional study included 15 patients with neovascular age-related macular degeneration refractory to anti-vascular endothelial growth factor. Patients used topical dorzolamide-timolol twice daily in the neovascular age-related macular degeneration eye and received anti-vascular endothelial growth factor therapy at each visit, with the same fixed interval and agent as before the addition of dorzolamide-timolol. Central macular thickness, maximal subretinal fluid height, and maximal pigment epithelial detachment height were measured at baseline and every visit. RESULTS: The mean follow-up period was 17.2 ± 5.5 weeks. The mean central macular thickness decreased from 383.5 μm at baseline to 298.3 μm at the final visit (P = 0.041). The mean maximal subretinal fluid height decreased from 105.0 μm at baseline to 58.3 μm at the final visit (P = 0.021). Complete resolution of subretinal fluid was observed in 3 of 11 subretinal fluid-type eyes. There was no significant change in the maximal pigment epithelial detachment height. The mean logarithm of the minimum angle of resolution visual acuity decreased from 0.61 (20/81 Snellen) at baseline to 0.66 (20/91 Snellen) at final visit, which was not significant (P = 0.314). The mean intraocular pressure decreased significantly from 14.9 mmHg at baseline to 12.3 mmHg at the final visit (P = 0.005). CONCLUSION: The use of adjuvant topical dorzolamide-timolol was effective in decreasing central macular thickness and subretinal fluid in patients with neovascular age-related macular degeneration refractory to continual fixed-interval intravitreal anti-vascular endothelial growth factor therapy, but did not result in functional improvement in this short-term study.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfRETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEFFICACY OF ADJUVANT TOPICAL DORZOLAMIDE-TIMOLOL IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION REFRACTORY TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorLee, Ji Hwan-
dc.contributor.googleauthorLee, Sung Chul-
dc.contributor.googleauthorByeon, Suk Ho-
dc.contributor.googleauthorKoh, Hyoung Jun-
dc.contributor.googleauthorKim, Sung Soo-
dc.contributor.googleauthorLee, Christopher Seungkyu-
dc.identifier.doi10.1097/IAE.0000000000002293-
dc.contributor.localIdA00152-
dc.contributor.localIdA00571-
dc.contributor.localIdA01849-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA03222-
dc.relation.journalcodeJ02621-
dc.identifier.eissn1539-2864-
dc.identifier.pmid30161096-
dc.identifier.urlhttps://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-201910000-00014&LSLINK=80&D=ovft-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.affiliatedAuthor고형준-
dc.contributor.affiliatedAuthor김성수-
dc.contributor.affiliatedAuthor변석호-
dc.contributor.affiliatedAuthor이성철-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이지환-
dc.citation.volume39-
dc.citation.number10-
dc.citation.startPage1953-
dc.citation.endPage1958-
dc.identifier.bibliographicCitationRETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol.39(10) : 1953-1958, 2019-
dc.identifier.rimsid63713-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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