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Sarcopenia and Sarcopenic Obesity as Novel Risk Factors for Gastric Carcinogenesis: A Health Checkup Cohort Study

DC FieldValueLanguage
dc.contributor.author김지현-
dc.contributor.author박효진-
dc.contributor.author백수정-
dc.contributor.author윤영훈-
dc.contributor.author천재영-
dc.contributor.author김영민-
dc.date.accessioned2019-12-18T01:23:12Z-
dc.date.available2019-12-18T01:23:12Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173496-
dc.description.abstractBackground: Insulin resistance, the primary mechanism of metabolic syndrome, promotes gastric carcinogenesis. Metabolic syndrome is associated with sarcopenia. We aimed to investigate the association between sarcopenia and gastric carcinogenesis, including precancerous conditions such as atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia. Methods: The study included adult patients who underwent gastroduodenoscopy at a checkup center. AG and IM were evaluated using endoscopy. Based on muscle mass, sarcopenia was defined as a skeletal muscle index <1 standard deviation below the sex-specific mean for healthy adults aged 20–39 years (cutoff point: 29.3% for males and 26.7% for females). Obesity was defined as a body mass index (BMI) ≥25 kg/m2 accordingtotheAsia-Pacificcriteria.Sarcopenicobesitywasdefinedasacombinationof sarcopenia and obesity. The association between gastric carcinogenesis and sarcopenia was evaluated. Results: Among 8,356 enrolled participants, 0.14 and 42.5% were diagnosed with gastric cancer and precancerous conditions, respectively. Approximately 41.7% of gastric cancer patients and 16.9% of patients with precancerous conditions were diagnosed with sarcopenia. Both sarcopenic obesity (odds ratio [OR] = 4.139, P = 0.016) and diabetes mellitus (DM) (OR = 5.152, P = 0.005) were significantly associated with gastric cancer. Sarcopenia, DM, hypertension, dyslipidemia, Helicobacter pylori infection, smoking, and alcohol consumption were significantly associated with precancerous conditions. Conclusions: Sarcopenia and sarcopenic obesity were associated with gastric carcinogenesis and may be novel risk factors for gastric carcinogenesis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSarcopenia and Sarcopenic Obesity as Novel Risk Factors for Gastric Carcinogenesis: A Health Checkup Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoung Min Kim-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorSu Jung Baik-
dc.contributor.googleauthorJaeyoung Chun-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.identifier.doi10.3389/fonc.2019.01249-
dc.contributor.localIdA00996-
dc.contributor.localIdA01774-
dc.contributor.localIdA01774-
dc.contributor.localIdA04580-
dc.contributor.localIdA04580-
dc.contributor.localIdA02583-
dc.contributor.localIdA02583-
dc.contributor.localIdA05701-
dc.contributor.localIdA05701-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.subject.keywordgastric carcinogenesis-
dc.subject.keywordsarcopenia-
dc.subject.keywordsarcopenic obesity-
dc.subject.keywordmetabolic syndrome-
dc.subject.keywordrisk factor-
dc.contributor.alternativeNameKim, Jie-Hyun-
dc.contributor.affiliatedAuthor김지현-
dc.contributor.affiliatedAuthor박효진-
dc.contributor.affiliatedAuthor박효진-
dc.contributor.affiliatedAuthor백수정-
dc.contributor.affiliatedAuthor백수정-
dc.contributor.affiliatedAuthor윤영훈-
dc.contributor.affiliatedAuthor윤영훈-
dc.contributor.affiliatedAuthor천재영-
dc.contributor.affiliatedAuthor천재영-
dc.citation.volume9-
dc.citation.startPage1249-
dc.identifier.bibliographicCitationFRONTIERS IN ONCOLOGY, Vol.9 : 1249, 2019-
Appears in Collections:
7. Others (기타) > Gangnam Severance Hospital (강남세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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