86 84

Cited 5 times in

Diagnostic performance of CA 125, HE4, and risk of Ovarian Malignancy Algorithm for ovarian cancer

Authors
 Boyeon Kim  ;  Yongjung Park  ;  Banseok Kim  ;  Hyo Jun Ahn  ;  Kyung‐A Lee  ;  Jae Eun Chung  ;  Sang Won Han 
Citation
 JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.33(1) : e22624, 2019 
Journal Title
 JOURNAL OF CLINICAL LABORATORY ANALYSIS 
ISSN
 0887-8013 
Issue Date
2019
MeSH
Adult ; Aged ; Algorithms ; Biomarkers, Tumor/blood ; CA-125 Antigen/blood* ; Female ; Humans ; Menopause ; Middle Aged ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/diagnosis* ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/pathology ; Proteins/analysis* ; Risk ; Sensitivity and Specificity
Abstract
OBJECTIVE: We evaluated the diagnostic performance of CA 125, HE4, and ROMA for ovarian cancer in Koreans and set optimal cutoffs. METHOD: Serum levels of HE4 and CA 125 and the ROMA score were determined in 762 patients with benign gynecological disease and 70 with ovarian cancer. Receiver operating characteristic curves were constructed to calculate the areas under the curve (AUC). CA 125, HE4, and ROMA exhibiting maximum Youden index were determined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs. RESULTS: In benign diseases, CA 125 significantly increased in patients with uterine myoma, adenomyosis, endometrial pathology, or endometriosis, but HE4 only increased in patients with adenomyosis. For the diagnosis of ovarian cancer, the combination of CA 125, HE4, and age showed the highest AUC value of 0.892 in the premenopausal group, and ROMA demonstrated the best diagnostic performance, with an AUC of 0.935 in postmenopausal patients. When the optimal cutoff values for CA 125 and HE4 were applied, the sensitivities of CA 125, HE4, and ROMA in premenopausal women were all the same at 0.714, while the specificities were 0.841, 0.974, and 0.972, respectively. In the postmenopausal group, the sensitivities of these markers were 0.857, 0.804, and 0.929, and the specificities were 0.836, 0.887, and 0.800, respectively. CONCLUSION: Although all markers demonstrated good diagnostic performance, they varied depending on the pathologic types of benign diseases and ovarian cancer. For accurate diagnosis of ovarian cancer, CA 125, HE4, and ROMA should be used complementarily.
Files in This Item:
T201904706.pdf Download
DOI
10.1002/jcla.22624
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173480
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links