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The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study

Authors
 Hee-Young Yoon  ;  Han-Na Kim  ;  Su Hwan Lee  ;  Soo Jung Kim  ;  Yoosoo Chang  ;  Seungho Ryu  ;  Hocheol Shin  ;  Hyung-Lae Kim  ;  Jin Hwa Lee 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.8(2) : E230, 2019 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2019
Keywords
16S RNA ; Faecalibacterium ; gut microbiota ; platelet ; thrombocytosis
Abstract
Platelet count reflects the severity and prognosis of multiple diseases. Additionally, alterations in gut microbiota have been linked to several chronic diseases. The purpose of this study was to investigate the association between gut microbiota and platelet count. We selected 1268 subjects with fecal 16S RNA gene sequencing data from a Healthcare Screening Center cohort. Based on the third quartile of platelets (277 × 10⁸/L), we compared the gut microbiota between the upper quartile (n = 321) and lower three quartiles groups (n = 947). The upper quartile group had lower alpha diversity based on observed amplicon sequence variants (q = 0.004) and phylogenetic index (q < 0.001) than the lower three quartiles group. Significant differences were also found in the weighted UniFrac distance (q = 0.001) and Jaccard dissimilarity (q = 0.047) beta diversity measures between the two groups. Compared with the lower three quartiles group, the upper quartile group exhibited decreased relative abundances of the genus Faecalibacterium, which was also inversely correlated with the platelet count. Increased platelet count was associated with reduced diversity in gut microbiota and lower abundances of Faecalibacterium with beneficial gut bacteria spices F. prausnitzii, suggesting that an increased platelet count, even within normal range, may adversely affect gut microbial diversity and composition.
Files in This Item:
T201904620.pdf Download
DOI
10.3390/jcm8020230
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Su Hwan(이수환) ORCID logo https://orcid.org/0000-0002-3487-2574
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173421
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