Cited 185 times in
Microsatellite Instability and Programmed Cell Death-Ligand 1 Expression in Stage II/III Gastric Cancer: Post Hoc Analysis of the CLASSIC Randomized Controlled study
DC Field | Value | Language |
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dc.contributor.author | 김현기 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 이진애 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 최승호 | - |
dc.contributor.author | 최윤영 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2019-12-18T01:11:00Z | - |
dc.date.available | 2019-12-18T01:11:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173408 | - |
dc.description.abstract | OBJECTIVE: We investigated microsatellite instability (MSI) status and programed cell death ligand 1 (PD-L1) expression as predictors of prognosis and responsiveness to chemotherapy for stage II/III gastric cancer. BACKGROUND: The clinical implications of MSI status and PD-L1 expression in gastric cancer have not been well-elucidated. METHODS: Tumor specimens and clinical information were collected from patients enrolled in the CLASSIC trial-a randomized controlled study of capecitabine plus oxaliplatin-based adjuvant chemotherapy. Five quasi-monomorphic mononucleotide markers were used to assess tumor MSI status. PD-L1 expressions of tumor and stromal immune cells were evaluated using immunohistochemistry. RESULTS: Of 592 patients, 40 (6.8%) had MSI-high (MSI-H) tumors. Among 582 patients available for immunohistochemistry evaluation, PD-L1 was positive in tumor cells (tPD-L1) of 16 patients (2.7%) and stromal immune cells (sPD-L1) of 165 patients (28.4%). Multivariable analysis of disease-free survival (DFS) showed that MSI-H and sPD-L1-positivity were independent prognostic factors [hazard ratio 0.301 (0.123-0.736), 0.714 (0.514-0.991); P = 0.008, 0.044), as were receiving chemotherapy, age, tumor grade, and TNM stage. Although adjuvant chemotherapy improved DFS in the microsatellite-stable (MSS) group (5-year DFS: 66.8% vs 54.1%; P = 0.002); no benefit was observed in the MSI-H group (5-year DFS: 83.9% vs 85.7%; P = 0.931). In the MSS group, sPD-L1-negative patients, but not sPD-L1-positive patients, had significant survival benefit from adjuvant chemotherapy compared with surgery only (5-year DFS: 66.1% vs 50.7%; P = 0.001). CONCLUSION: MSI status and PD-L1 expression are clinically actionable biomarkers for stratifying patients and predicting benefit from adjuvant chemotherapy after D2 gastrectomy for stage II/III gastric cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANNALS OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Microsatellite Instability and Programmed Cell Death-Ligand 1 Expression in Stage II/III Gastric Cancer: Post Hoc Analysis of the CLASSIC Randomized Controlled study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Choi, Yoon Young | - |
dc.contributor.googleauthor | Kim, Hyunki | - |
dc.contributor.googleauthor | Shin, Su-Jin | - |
dc.contributor.googleauthor | Kim, Ha Yan | - |
dc.contributor.googleauthor | Lee, Jinae | - |
dc.contributor.googleauthor | Yang, Han-Kwang | - |
dc.contributor.googleauthor | Kim, Woo Ho | - |
dc.contributor.googleauthor | Kim, Young-Woo | - |
dc.contributor.googleauthor | Kook, Myeong-Cherl | - |
dc.contributor.googleauthor | Park, Young Kyu | - |
dc.contributor.googleauthor | Kim, Hyung-Ho | - |
dc.contributor.googleauthor | Lee, Hye Seung | - |
dc.contributor.googleauthor | Lee, Kyung Hee | - |
dc.contributor.googleauthor | Gu, Mi Jin | - |
dc.contributor.googleauthor | Choi, Seung Ho | - |
dc.contributor.googleauthor | Hong, SoonWon | - |
dc.contributor.googleauthor | Kim, Jong Won | - |
dc.contributor.googleauthor | Hyung, Woo Jin | - |
dc.contributor.googleauthor | Noh, Sung Hoon | - |
dc.contributor.googleauthor | Cheong, Jae-Ho | - |
dc.identifier.doi | 10.1097/SLA.0000000000002803 | - |
dc.contributor.localId | A00925 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A04641 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A04102 | - |
dc.contributor.localId | A04138 | - |
dc.contributor.localId | A04382 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J00178 | - |
dc.identifier.eissn | 1528-1140 ( | - |
dc.identifier.pmid | 29727332 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000658-201908000-00018&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Kim, Jong Won | - |
dc.contributor.affiliatedAuthor | 김현기 | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.contributor.affiliatedAuthor | 이진애 | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.contributor.affiliatedAuthor | 최승호 | - |
dc.contributor.affiliatedAuthor | 최윤영 | - |
dc.contributor.affiliatedAuthor | 형우진 | - |
dc.contributor.affiliatedAuthor | 홍순원 | - |
dc.citation.volume | 270 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 309 | - |
dc.citation.endPage | 316 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGERY, Vol.270(2) : 309-316, 2019 | - |
dc.identifier.rimsid | 63958 | - |
dc.type.rims | ART | - |
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