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Prognostic significance of high metabolic activity in breast cancer: PET signature in breast cancer

Authors
 Sanghee Kang  ;  Eui Hyun Kim  ;  Jun-Eul Hwang  ;  Ji-Hyun Shin  ;  Yun Seong Jeong  ;  Sun Young Yim  ;  Eun Wook Joo  ;  Young Gyu Eun  ;  Dong Jin Lee  ;  Bo Hwa Sohn  ;  Sung Hwan Lee  ;  Bora Lim  ;  Ju-Seog Lee 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.511(1) : 185-191, 2019 
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN
 0006-291X 
Issue Date
2019
Keywords
(18)F-fluorodeoxy-glucose ; Breast cancer ; MYC ; Positron emission tomography ; TBX2
Abstract
High metabolic activity, reflected in increased glucose uptake, is one of the hallmarks of many cancers including breast cancer. However, not all cancers avidly take up glucose, suggesting heterogeneity in their metabolic demand. Thus, we aim to generate a genomic signature of glucose hypermetabolism in breast cancer and examine its clinical relevance. To identify genes significantly associated with glucose uptake, gene expression data were analyzed together with the standardized uptake values (SUVmax) of 18F-fluorodeoxy-glucose on positron emission tomography (PET) for 11 breast cancers. The resulting PET signature was evaluated for prognostic significance in four large independent patient cohorts (n = 5417). Potential upstream regulators accountable for the high glucose uptake were identified by gene network analysis. A PET signature of 242 genes was significantly correlated with SUVmax in breast cancer. In all four cohorts, high PET signature was significantly associated with poorer prognosis. The prognostic value of this PET signature was further supported by Cox regression analyses (hazard ratio 1.7, confidential interval 1.48-2.02; P < 0.001). The PET signature was also strongly correlated with previously established prognostic genomic signatures such as PAM50, Oncotype DX, and NKI. Gene network analyses suggested that MYC and TBX2 were the most significant upstream transcription factors in the breast cancers with high glucose uptake. A PET signature reflecting high glucose uptake is a novel independent prognostic factor in breast cancer. MYC and TBX2 are potential regulators of glucose uptake.
Full Text
https://www.sciencedirect.com/science/article/pii/S0006291X19302220
DOI
10.1016/j.bbrc.2019.02.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eui Hyun(김의현) ORCID logo https://orcid.org/0000-0002-2523-7122
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173400
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