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Assessment of patient-reported outcomes (PROs): treatment satisfaction, medication adherence, and quality of life (QoL) and the associated factors in postmenopausal osteoporosis (PMO) patients in Korea

Authors
 Dong Won Byun  ;  Seong-Hwan Moon  ;  Tak Kim  ;  Hae-Hyeog Lee  ;  Hyoung Moo Park  ;  Moo-Il Kang  ;  Yong-Chan Ha  ;  Ho-Yeon Chung  ;  Byung-Koo Yoon  ;  Tae-Young Kim  ;  Soo Uk Chae  ;  Chan Soo Shin  ;  Kyu-Hyun Yang  ;  Jae Hyup Lee  ;  Jae Suk Chang  ;  Sung Hoon Kim  ;  In Joo Kim  ;  Jung-Min Koh  ;  Jung Hwa Jung  ;  Kyong Wook Yi  ;  Jeong Joon Yoo  ;  Dong Jin Chung  ;  Young-Kyun Lee  ;  Hyun-Koo Yoon  ;  Seongbin Hong  ;  Deog-Yoon Kim  ;  Ki Hyun Baek  ;  Hyun-Joo Kim  ;  Young-Joo Kim  ;  Seongsik Kang  ;  Yong-Ki Min 
Citation
 JOURNAL OF BONE AND MINERAL METABOLISM, Vol.37(3) : 563-572, 2019 
Journal Title
 JOURNAL OF BONE AND MINERAL METABOLISM 
ISSN
 0914-8779 
Issue Date
2019
MeSH
Bone Density Conservation Agents/therapeutic use ; Cross-Sectional Studies ; Diphosphonates/therapeutic use ; Female ; Humans ; Medication Adherence*/statistics & numerical data ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/epidemiology* ; Patient Reported Outcome Measures* ; Patient Satisfaction* ; Quality of Life* ; Republic of Korea ; Surveys and Questionnaires ; Treatment Outcome
Keywords
Gastrointestinal events ; Medication adherence ; Postmenopausal osteoporosis ; Quality of life ; Treatment satisfaction
Abstract
Patient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected. The 14-item Treatment Satisfaction Questionnaire for Medication (TSQM) (score-range, 0-100; domains: effectiveness, side effects, convenience, global satisfaction), Osteoporosis-Specific Morisky Medication Adherence Scale (OS-MMAS) (score-range, 0-8), and EuroQol-5 dimensions questionnaire (index score range, - 0.22 to 1.0; EuroQol visual analog scale score range, 0-100) were used. To investigate factors associated with PROs, linear (treatment satisfaction/QoL) or logistic (medication adherence) regression analyses were conducted. A total of 1804 patients (age, 62 years) were investigated; 60.1% used bisphosphonate, with the majority (67.2%) using weekly medication, 27.8% used daily hormone replacement therapy, and 12.1% used daily selective estrogen receptor modulator. Several patients reported gastrointestinal (GI) events (31.6%) and dental visits due to problems (24.1%) while using medication. Factors associated with the highest OS-MMAS domain scores were convenience and global satisfaction. GI events were associated with non-adherence. TSQM scores for effectiveness, side effects, and GI risk factors were significantly associated with QoL. Our study elaborately assessed the factors associated with PROs of Korean PMO women. Based on our findings, appropriate treatment-related adjustments such as frequency/choice of medications and GI risk management may improve PROs.
Full Text
https://link.springer.com/article/10.1007%2Fs00774-018-0956-6
DOI
10.1007/s00774-018-0956-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seong Hwan(문성환)
Yang, Kyu Hyun(양규현) ORCID logo https://orcid.org/0000-0001-7183-588X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173373
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