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Relation of Preprocedural Hemoglobin Level to Outcomes After Percutaneous Coronary Intervention

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dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김효은-
dc.contributor.author신동호-
dc.contributor.author이병권-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.contributor.author홍성진-
dc.contributor.author김병규-
dc.contributor.author안철민-
dc.date.accessioned2019-12-18T01:06:52Z-
dc.date.available2019-12-18T01:06:52Z-
dc.date.issued2019-
dc.identifier.issn0002-9149-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173371-
dc.description.abstractAdverse effects have been reported in patients with preprocedural anemia after percutaneous coronary intervention (PCI), but data regarding the relation between elevated hemoglobin (Hb) level and post-PCI prognosis remain limited. This study assessed the impact of elevated Hb on major adverse cardiac and cerebrovascular event (MACCE) at 12 months, a composite of all-cause mortality, nonfatal myocardial infarction, and ischemic stroke after PCI. We pooled patient-level data from four Korean multicenter drug-eluting stent registries from 2010 to 2016. In total, 5,107 patients were divided into 5 categories according to the baseline Hb level (<10, 10 to 12.9, 13 to 14.9, 15 to 16.9 and ≥17 g/dl). Patients with higher Hb levels were significantly younger, predominantly male, current smokers with higher body mass index, and more frequent dyslipidemia. Hypertension, diabetes, chronic kidney disease, and cerebrovascular accident were more prevalent in lower Hb groups. Categorically, a U-shaped curvilinear relation was observed between baseline Hb and clinical outcomes showing significantly higher MACCE rate in <10g/dl (hazard ratio [HR], 4.62 [2.81 to 7.68]) and ≥17 g/dl (HR, 4.06 [1.57 to 10.5]) groups compared with the reference group (13 to 14.9 g/dl), especially in men. In nonanemic patients (Hb ≥13 g/dl), adjusted HRs of MACCE, mortality, and stroke were significantly higher in ≥17 g/dl group than in the reference group. Furthermore, ≥17 g/dl was an independent predictor for MACCE and all-cause mortality after PCI. In conclusion, not only low Hb but also elevated Hb of ≥17 g/dl was significantly associated with higher MACCE rates and all-cause mortality after PCI. An appropriate treatment strategy for patients with high Hb level should be identified through future studies.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherExcerpta Medica-
dc.relation.isPartOfAMERICAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRelation of Preprocedural Hemoglobin Level to Outcomes After Percutaneous Coronary Intervention-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorByung Gyu Kim-
dc.contributor.googleauthorHyoeun Kim-
dc.contributor.googleauthorSung-Jin Hong-
dc.contributor.googleauthorChul-Min Ahn-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorByoung Kwon Lee-
dc.identifier.doi10.1016/j.amjcard.2019.07.056-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA05772-
dc.contributor.localIdA02097-
dc.contributor.localIdA05648-
dc.contributor.localIdA02793-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA04403-
dc.relation.journalcodeJ00071-
dc.identifier.eissn1879-1913-
dc.identifier.pmid31493827-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0002914919308872-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.affiliatedAuthor고영국-
dc.contributor.affiliatedAuthor김병극-
dc.contributor.affiliatedAuthor김효은-
dc.contributor.affiliatedAuthor신동호-
dc.contributor.affiliatedAuthor안철민-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor장양수-
dc.contributor.affiliatedAuthor최동훈-
dc.contributor.affiliatedAuthor홍명기-
dc.contributor.affiliatedAuthor홍성진-
dc.citation.volume124-
dc.citation.number9-
dc.citation.startPage1319-
dc.citation.endPage1326-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CARDIOLOGY, Vol.124(9) : 1319-1326, 2019-
dc.identifier.rimsid63611-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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