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Stretchable ECM Patch Enhances Stem Cell Delivery for Post-MI Cardiovascular Repair

Authors
 In Gul Kim  ;  Mintai P. Hwang  ;  Jin Sil Park  ;  Su‐Hyun Kim  ;  Jung‐Hyun Kim  ;  Hyo Jin Kang  ;  Ramesh Subbiah  ;  Ung Hyun Ko  ;  Jennifer H. Shin  ;  Chong‐Hyun Kim  ;  Donghoon Choi  ;  Kwideok Park 
Citation
 ADVANCED HEALTHCARE MATERIALS, Vol.8(17) : e1900593, 2019 
Journal Title
 ADVANCED HEALTHCARE MATERIALS 
ISSN
 2192-2640 
Issue Date
2019
Keywords
cardiac patches ; extracellular matrix (ECM) ; mesenchymal stem cells ; myocardial infarction ; polyvinyl alcohol (PVA)
Abstract
Current cell-based therapies administered after myocardial infarction (MI) show limited efficacy due to subpar cell retention in a dynamically beating heart. In particular, cardiac patches generally provide a cursory level of cell attachment due to the lack of an adequate microenvironment. From this perspective, decellularized cell-derived ECM (CDM) is attractive in its recapitulation of a natural biophysical environment for cells. Unfortunately, its weak physical property renders it difficult to retain in its original form, limiting its full potential. Here, a novel strategy to peel CDM off from its underlying substrate is proposed. By physically stamping it onto a polyvinyl alcohol hydrogel, the resulting stretchable extracellular matrix (ECM) membrane preserves the natural microenvironment of CDM, thereby conferring a biological interface to a viscoelastic membrane. Its various mechanical and biological properties are characterized and its capacity to improve cardiomyocyte functionality is demonstrated. Finally, evidence of enhanced stem cell delivery using the stretchable ECM membrane is presented, which leads to improved cardiac remodeling in a rat MI model. A new class of material based on natural CDM is envisioned for the enhanced delivery of cells and growth factors that have a known affinity with ECM.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201900593
DOI
10.1002/adhm.201900593
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hyo Jin(강효진)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173331
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