0 44

Cited 0 times in

Loss of Both USP10 and p14ARF Protein Expression Is an Independent Prognostic Biomarker for Poor Prognosis in Patients With Epithelial Ovarian Cancer

Authors
 GWAN HEE HAN  ;  DOO BYUNG CHAY  ;  JOO MI YI  ;  HANBYOUL CHO  ;  JOON-YONG CHUNG  ;  JAE-HOON KIM 
Citation
 Cancer genomics & Proteomics, Vol.16(6) : 553-562, 2019 
Journal Title
 Cancer genomics & Proteomics 
ISSN
 1109-6535 
Issue Date
2019
Keywords
Epithelial ovarian cancer ; USP10 ; p14ARF ; tumor marker
Abstract
BACKGROUND/AIM: The prognostic role of USP10 in epithelial ovarian cancer has been studied in various human cancers. Our aim was to evaluate the clinical and pathological significance of USP10 in epithelial ovarian cancer. MATERIALS AND METHODS: Immunohistochemical analyses of the expression of USP10 and p14ARF by using tissue microarrays were performed in 336 ovarian tumours and the data were compared with clinicopathological variables. We examined their level of DNA methylation around the putative transcriptional start site in 5' CpG islands in fresh frozen tissues and ovarian cancer cells. RESULTS: Expression of USP10 and p14ARF was significantly lower in cancer tissues than in normal epithelium. Low USP10 expression and a combined USP10/p14ARF low expression were revealed to be independent prognostic factors. A high degree of methylation in USP10 and p14ARF CpG islands was found by methylation specific PCR analysis in cancer than in normal tissues and cells. CONCLUSION: Decreased expression of USP10 or combined USP10/p14ARF decreased expression is a strong indicator of poor prognosis in patients with ovarian cancer.
Full Text
http://cgp.iiarjournals.org/content/16/6/553.long
DOI
10.21873/cgp.20157
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
Chay, Doo Byung(채두병) ORCID logo https://orcid.org/0000-0002-0648-4021
Han, Gwan Hee(한관희) ORCID logo https://orcid.org/0000-0001-5263-4855
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173307
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse