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Impact of multi-vessel vasospastic angina on cardiovascular outcome

Authors
 Seung Hwan Han  ;  Kwan Yong Lee  ;  Sung Ho Her  ;  Youngkeun Ahn  ;  Keun-Ho Park  ;  Dong-Soo Kim  ;  Tae-Hyun Yang  ;  Dong-Ju Choi  ;  Jung-Won Suh  ;  Hyuck Moon Kwon  ;  Byoung Kwon Lee  ;  Hyeon-Cheol Gwon  ;  Seung-Woon Rha  ;  Sang-Ho Jo  ;  Kwang-Pil Ko  ;  Sang Hong Baek 
Citation
 ATHEROSCLEROSIS, Vol.281(.) : 107-113, 2019 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2019
Keywords
Coronary artery disease ; Multi-vessel ; Prognosis ; Vasospasm
Abstract
BACKGROUND AND AIMS: Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans. METHODS: Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation test. RESULTS: Multi-vessel VSA and single vessel VSA groups showed similar baseline characteristics and medical treatment on discharge, but different from the non-VSA group. The primary composite endpoint (cardiac death, acute coronary syndrome, and symptomatic new onset arrhythmia) over a 36-month follow-up period was significantly higher in the multi-vessel VSA group than in the single vessel VSA and non-VSA groups (8.7% vs. 1.8% and 1.1%, each log-rank p < 0.05, respectively). The rate of death and acute coronary syndrome of the multi-vessel VSA group was higher than in the single vessel VSA and non-VSA groups (5.8% vs. 1.2% and 0.9%, each log-rank p < 0.05, respectively). In addition, multi-vessel VSA was an independent predictor of the primary composite endpoint at 36 months (HR 8.5, 95% CI [2.6-27.2], p < 0.0001). CONCLUSIONS: Patients with multi-vessel VSA had worse clinical outcomes than single vessel VSA and non-VSA groups, suggesting that the existence of multi-vessel VSA itself is highly prognostic.
Full Text
https://www.sciencedirect.com/science/article/pii/S0021915018315491
DOI
10.1016/j.atherosclerosis.2018.12.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173283
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