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Inflammasomes and autoimmune and rheumatic diseases: A comprehensive review

Authors
 Jae Il Shin  ;  Keum Hwa Lee  ;  Yo Han Joo  ;  Jiwon M. Lee  ;  Jaewook Jeon  ;  Hee Jae Jung  ;  Minkyue Shin  ;  Seobum Cho  ;  Tae Hwan Kim  ;  Seonghyuk Park  ;  Bong Yeol Jeon  ;  Hyunwoo Jeong  ;  Kangto Lee  ;  Kyutae Kang  ;  Myungsuk Oh  ;  Hansang Lee  ;  Seungchul Lee  ;  Yeji Kwon  ;  Geun ho Oh  ;  Andreas Kronbichler 
Citation
 Journal of Autoimmunity, Vol.103 : 102299, 2019 
Journal Title
 Journal of Autoimmunity 
ISSN
 0896-8411 
Issue Date
2019
Keywords
Autoimmunity ; Caspase-1 ; Inflammasome ; Interleukin-1β
Abstract
Inflammasomes are a multi-protein platform forming a part of the innate immune system. Inflammasomes are at standby status and can be activated when needed. Inflammasome activation is an important mechanism for the production of active interleukin (IL)-1β and IL-18, which have important roles to instruct adaptive immunity. Active forms of inflammasomes trigger a series of inflammatory cascades and lead to the differentiation and polarization of naïve T cells and secretion of various cytokines, which can induce various kinds of autoimmune and rheumatic diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), gout, Sjögren's syndrome, Behçet's disease, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and IgA vasculitis (former Henoch-Schönlein purpura ). In this review, we summarize studies published on inflammasomes and review their roles in various autoimmune diseases. Understanding of the role of inflammasomes may facilitate the diagnosis of autoimmune diseases and the development of tailored therapies in the future.
Full Text
https://www.sciencedirect.com/science/article/pii/S0896841119302264
DOI
10.1016/j.jaut.2019.06.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173272
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