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Renal Cell Carcinoma With Hemangioma-Like Features: Diagnostic Implications and Review of the Literature

Authors
 Eun Kyung Kim  ;  Mi Jang  ;  Yoon Jung Choi  ;  Nam Hoon Cho 
Citation
 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, Vol.27(6) : 631-638, 2019 
Journal Title
 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 
ISSN
 1066-8969 
Issue Date
2019
Keywords
differential diagnosis ; hemangioblastoma ; hemangioma ; immunohistochemistry ; renal cell carcinoma
Abstract
Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Case 2 consisted of homogeneously delicate microvascular proliferations resembling a capillary hemangioma with scattered inconspicuous clear cells. The clear cells of Case 1 were PAX8(+), CK7(diffuse+), CA9(diffuse+, cup-shaped), and inhibin A(-). The hemangioblastoma-like areas were PAX8(+), CK7(-), CA9(diffuse+), and inhibin A(diffuse+). Case 2 showed PAX8(+), CK7(-), and CA9(diffuse+). They can be diagnostically challenging, and it is important to recognize that a pure hemangioma or hemangioblastoma of the kidneys is very rare, and that RCCs with clear cell morphology rarely exhibit hemangioma-like characteristics.
Full Text
https://journals.sagepub.com/doi/full/10.1177/1066896919840435
DOI
10.1177/1066896919840435
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Jang, Mi(장미) ORCID logo https://orcid.org/0000-0002-0153-9847
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173249
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