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담도 폐쇄증 환자의 카사이 수술 중 사용한 sevoflurane과 desflurane이 수술 후 간 기능에 미치는 영향

Other Titles
 The comparison of desflurane and sevoflurane on postoperative hepatic function of infant with biliary atresia undergoing Kasai operation 
 이지민  ;  김민수  ;  이혜미  ;  이정림  ;  박지훈 
 Anesthesia and Pain Medicine, Vol.14(3) : 272-279, 2019 
Journal Title
Anesthesia and Pain Medicine
Issue Date
Desflurane ; Infant ; Liver function tests ; Portoenterostomy, hepatic ; Sevoflurane
Background: Biliary atresia is an extrahepatic progressive obliterate cholangiopathy that
occurs in infants. Kasai procedure, a surgical method that can help re-establish bile flow
from the liver into the intestine, is its first line treatment. Since infants with biliary atresia
already have advanced hepatic dysfunction, all kinds of schemes should be considered to
minimize further liver damage during surgery. The objective of this study was to compare
the postoperative hepatic functions between the two commonly used inhalational anesthetics
in infants undergoing the Kasai procedure (i.e., desflurane and sevoflurane).
Methods: This prospective, randomized, double-blind, single-center, and parallel group
study included 40 children undergoing Kasai procedure. They were randomly allocated
to Group S (sevoflurane) or Group D (desflurane). All the patients were anesthetized with
designated anesthetic agent with the end-tidal concentration of about 0.8–1 minimum
alveolar concentration. Postoperative hepatic functions were assessed by aspartate
aminotransferase (AST), alanine aminotransferase (ALT), albumin, prothrombin time,
and total bilirubin.
Results: A total of 38 patients were selected for the study. In both groups, AST, ALT were
increased in magnitude to the peak on postoperative day 0 and decreased to preoperative
value at postoperative day 3. There were no significant differences between the
groups in any laboratory results related to liver function.
Conclusions: Sevoflurane and desflurane, inhalation anesthetics for maintaining anesthesia
used in infants undergoing the Kasai procedure, did not show any difference in
preserving postoperative hepatic function.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Soo(김민수) ORCID logo https://orcid.org/0000-0001-8760-4568
Lee, Jeong Rim(이정림) ORCID logo https://orcid.org/0000-0002-7425-0462
Lee, Jimin(이지민)
Lee, Hye Mi(이혜미) ORCID logo https://orcid.org/0000-0002-0432-1878
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