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Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

Authors
 Ali Guner  ;  Hyoung-Il Kim 
Citation
 JOURNAL OF GASTRIC CANCER, Vol.19(3) : 254-277, 2019 
Journal Title
 JOURNAL OF GASTRIC CANCER 
ISSN
 2093-582X 
Issue Date
2019
Keywords
Biomarkers ; Cancer ; Immune system ; Inflammation ; Outcome assessment
Abstract
Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters are used to assess the inflammatory status during cancer treatment. It is important to select the most optimal biomarker among these parameters. Additionally, suitable biomarkers must be examined if there are no known parameters. We briefly reviewed the published literature for the use of inflammatory parameters in the treatment of patients with cancer. Most studies on inflammation evaluated the correlation between host characteristics, effect of interventions, and clinical outcomes. Additionally, the levels of C-reactive protein, albumin, lymphocytes, and platelets were the most commonly used laboratory parameters, either independently or in combination with other laboratory parameters and clinical characteristics. Furthermore, the immune parameters are classically examined using flow cytometry, immunohistochemical staining, and enzyme-linked immunosorbent assay techniques. However, gene expression profiling can aid in assessing the overall peri-interventional immune status. The checklists of guidelines, such as STAndards for Reporting of Diagnostic accuracy and REporting recommendations for tumor MARKer prognostic studies should be considered when designing studies to investigate the inflammatory parameters. Finally, the data should be interpreted after adjusting for clinically important variables, such as age and cancer stage.
Files in This Item:
T201904263.pdf Download
DOI
10.5230/jgc.2019.19.e29
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173187
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