0 143

Cited 1 times in

Prognostic factors of acinar- or papillary-predominant adenocarcinoma of the lung

Authors
 Moonsik Kim  ;  Yeon Seung Chung  ;  Kyoung A Kim  ;  Hyo Sup Shim 
Citation
 LUNG CANCER, Vol.137 : 129-135, 2019 
Journal Title
 LUNG CANCER 
ISSN
 0169-5002 
Issue Date
2019
Keywords
Acinar ; Adenocarcinoma ; PD-L1 ; Papillary ; Prognosis ; Spread through air spaces
Abstract
OBJECTIVE: Histologic types are correlated with prognosis in lung adenocarcinoma. The acinar/papillary type is most common, although this group comprises heterogeneous tumor types. However, the prognostic factors in this group have not been well studied. Therefore, we investigated the prognostic factors of acinar/papillary lung adenocarcinomas and attempted to define the so-called "intermediate grade" group of lung adenocarcinoma. MATERIALS AND METHODS: We classified surgically resected invasive non-mucinous adenocarcinomas of the lung and analyzed their clinicopathological features and prognostic factors, focusing on the acinar/papillary type. RESULTS: A total of 301 cases with stage I-III lung adenocarcinoma were enrolled, of which 193 were acinar/papillary type (64.1%). In survival analysis of the entire cohort, acinar/papillary types showed intermediate survival compared with lepidic and micropapillary/solid types. In the univariate survival analysis for acinar/papillary types, stage, age, lymphovascular invasion, spread through air spaces, presence of micropapillary or solid pattern, and programmed death-ligand 1 (PD-L1) positivity were associated with poor recurrence-free survival and overall survival. In multivariate analysis, spread through air spaces and PD-L1 expression were independent poor prognostic factors of recurrence-free survival and overall survival in the acinar/papillary cohort, respectively. CONCLUSIONS: Evaluation of spread through air spaces and PD-L1 expression may be useful to stratify patients with acinar/papillary lung adenocarcinomas in terms of prognosis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0169500219306701
DOI
10.1016/j.lungcan.2019.09.026
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung A.(김경아)
Kim, Moonsik(김문식) ORCID logo https://orcid.org/0000-0002-5804-8790
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173175
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links