Cited 13 times in

Salmonella enterica Serovar Typhimurium Interacts with CD209 Receptors To Promote Host Dissemination and Infection

Authors
 Chenglin Ye  ;  Qiao Li  ;  Xinyi Li  ;  Chae Gyu Park  ;  Yingxia He  ;  Yingmiao Zhang  ;  Bicong Wu  ;  Ying Xue  ;  Kun Yang  ;  Yin Lv  ;  Xiao-Ling Ying  ;  Hong-Hui Ding  ;  Huahua Cai  ;  Ayman Ahmad Alkraiem  ;  Olivia Njiri  ;  John Tembo  ;  Hong-Ping Huang  ;  An-Yi Li  ;  Jianping Gong  ;  Jichao Qin  ;  Bing Cheng  ;  Xiang Wei  ;  Ziyong Sun  ;  Shu-Sheng Zhang  ;  Pei Zhang  ;  Guo-Xing Zheng  ;  Wei Li  ;  Biao Kan  ;  Meiying Yan  ;  Xiamu Xiding  ;  Xixiang Huo  ;  Yingchun Zeng  ;  Hua Peng  ;  Yangxin Fu  ;  John D. Klena  ;  Mikael Skurnik  ;  Ling-Yu Jiang  ;  Tie Chen 
Citation
 INFECTION AND IMMUNITY, Vol.87(8) : e00100-19, 2019 
Journal Title
INFECTION AND IMMUNITY
ISSN
 0019-9567 
Issue Date
2019
MeSH
Animals ; Antigen-Presenting Cells/microbiology ; Cell Adhesion Molecules/physiology* ; Female ; Host-Pathogen Interactions ; Humans ; Lectins, C-Type/physiology* ; Lipopolysaccharides/physiology ; Mannans/pharmacology ; Mice ; Mice, Inbred C57BL ; O Antigens/physiology ; Peyer's Patches/physiology ; Phagocytosis ; RAW 264.7 Cells ; Receptors, Cell Surface/physiology* ; Salmonella typhimurium/pathogenicity*
Keywords
CD209 ; S. Typhimurium ; dendritic cell ; dissemination ; lipooligosaccharide ; macrophages
Abstract
Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.
Full Text
https://iai.asm.org/content/87/8/e00100-19.long
DOI
10.1128/IAI.00100-19
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173129
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links