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Chordomas: Histopathological Study in View of Anatomical Location

Authors
 Yoon Jin Cha  ;  Yeon-Lim Suh 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.34(13) : e107, 2019 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2019
MeSH
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Chordoma/mortality ; Chordoma/pathology* ; Cranial Fossa, Posterior/pathology ; Disease-Free Survival ; Female ; Humans ; Ki-67 Antigen/metabolism ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Sacrum/pathology ; Skull Base Neoplasms/mortality ; Skull Base Neoplasms/pathology* ; Survival Rate ; Young Adult
Keywords
Bone Neoplasms ; Brain Neoplasms ; Chordoma ; Notochord ; Skull Base Neoplasms ; Soft Tissue Neoplasms
Abstract
BACKGROUND: Chordomas are aggressive bone tumors that have a predilection for the axial skeleton including the skull base and spinal/sacral bones. However, the histopathological and clinical differences between skull base chordoma (SBC) and sacral/spinal chordoma (SC) are unclear as previous studies have been focused on patient prognosis and treatment outcome. This study aimed to evaluate the clinicopathologic features and prognosis of chordoma according to its location. METHODS: Patients with chordomas were enrolled, and the histopathologic features were compared according to the tumor location. RESULTS: A total of 52 patients were enrolled. SBCs had more abundant chondroid matrix and diffuse growth pattern, while SCs had non-chondroid, myxoid matrix and a lobulating pattern, typical of chordoma. Old age and residual tumors were risk factors for shorter overall survival in SBCs. The chondroid matrix was an independent risk factor for shorter disease-free survival in the overall population. CONCLUSION: Chordomas have different histopathologic features depending on the anatomical location.
Files in This Item:
T201903963.pdf Download
DOI
10.3346/jkms.2019.34.e107
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173121
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