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Targeting Autophagy in Obesity-Associated Heart Disease

Authors
 Diana Castañeda  ;  Mohanad Gabani  ;  Soo‐Kyoung Choi  ;  Quynh My Nguyen  ;  Cheng Chen  ;  Ayesha Mapara  ;  Adam Kassan  ;  Alexis A. Gonzalez  ;  Karima Ait‐Aissa  ;  Modar Kassan 
Citation
 OBESITY, Vol.27(7) : 1050-1058, 2019 
Journal Title
OBESITY
ISSN
 1930-7381 
Issue Date
2019
Abstract
Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patients and mouse models with obesity, this process is impaired. Furthermore, it has been shown that autophagy flux restoration in obesity models improves cardiac function. Therefore, autophagy may play an important role in mitigating the adverse effects of obesity on the heart. Throughout this review, we will discuss the benefits of autophagy on the heart in obesity and how regulating autophagy might be a therapeutic tool to reduce the risk of obesity-associated cardiovascular diseases.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22455
DOI
10.1002/oby.22455
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Choi, Soo Kyoung(최수경) ORCID logo https://orcid.org/0000-0002-7115-6358
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173117
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