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Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study

 Keum Ji Jung  ;  Tae‐Gyun Kim  ;  Jae Won Lee  ;  Minseok Lee  ;  Jongwook Oh  ;  Sang‐Eun Lee  ;  Hyuk‐Jae Chang  ;  Sun Ha Jee  ;  Min‐Geol Lee 
 JOURNAL OF DERMATOLOGY, Vol.46(10) : 859-866, 2019 
Journal Title
Issue Date
Adult ; Angina Pectoris/epidemiology* ; Atherosclerosis/epidemiology* ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Myocardial Infarction/epidemiology* ; Prevalence ; Proportional Hazards Models ; Psoriasis/diagnosis ; Psoriasis/epidemiology* ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Sex Factors ; Stroke/epidemiology*
Korea ; atherosclerotic cardiovascular disease ; cohort study ; epidemiology ; psoriasis
The association between psoriasis and risk of atherosclerotic cardiovascular disease has not been thoroughly evaluated in a large longitudinal cohort of an Asian population. We conducted a nationwide population-based retrospective cohort study encompassing more than 1.7 million Koreans with a 15-year follow-up period. The period prevalence of psoriasis was 0.33% among the baseline participants (1997-2000). In Cox proportional hazard analyses, the individuals with psoriasis had a higher adjusted hazard ratio (HR) for incidence of overall atherosclerotic cardiovascular disease (HR, 1.18; 95% confidence interval [CI], 1.09-1.27) compared with controls. Subgroup analyses revealed that the risk for myocardial infarction was commonly increased in both sexes with moderate to severe psoriasis (male: HR, 2.09; 95% CI, 1.35-3.24; female: HR, 3.23; 95% CI, 1.34-7.76), whereas the risk for ischemic stroke was specifically increased in female individuals with moderate to severe psoriasis (HR, 2.02; 95% CI, 1.24-3.30). Our data suggest that appropriate medical screening for possible cardiovascular comorbidities is warranted in Asian psoriatic patients according to disease severity and sex.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Oh, Jongwook(오종욱)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Lee, Jae Won(이재원)
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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