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Pathophysiologic Findings in the Human Endolymphatic Sac in Endolymphatic Hydrops: Functional and Molecular Evidence

Authors
 Sung Huhn Kim  ;  Gi-Sung Nam  ;  Jae Young Choi 
Citation
 ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, Vol.128(6Suppl.) : 76s-83s, 2019 
Journal Title
 ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 
ISSN
 0003-4894 
Issue Date
2019
MeSH
Endolymphatic Hydrops/etiology* ; Endolymphatic Sac/physiopathology* ; Humans
Keywords
Meniere’s disease ; endolymphatic hydrops ; endolymphatic sac
Abstract
BACKGROUND: The endolymphatic sac (ES) is a cystic structure situated on the posterior fossa dura and is connected to the luminal space of the vestibular organ through the endolymphatic duct, which branches into the utricular and saccular ducts. Unlike the cochlea and vestibule, the ES does not contain sensory epithelium in its luminal space, and a single layer of epithelial cells line the luminal surface area. The ES in the inner ear is thought to play a role in the regulation of inner ear homeostasis, fluid volume, and immune reaction. If these functions of the ES are disrupted, dysfunction of the inner ear may develop. The most well-known pathology arising from dysfunction of the ES is endolymphatic hydrops, characterized by an enlarged endolymphatic space due to the accumulation of excessive endolymphatic fluid. Although, molecular identities and functional evidence for the roles were identified in animal studies, basic studies of the human ES are relatively uncommon compared with those using animal tissues, because of limited opportunity to harvest the human ES. METHODS: In this study, molecular and functional evidence for the role of the human ES in the development of endolymphatic hydrops are reviewed. RESULTS AND CONCLUSIONS: Although evidence is insufficient, studies using the human ES have mostly produced findings similar to those of animal studies. This review may provide a basis for planning further studies to investigate the pathophysiology of disorders with the finding of endolymphatic hydrops.
Full Text
https://journals.sagepub.com/doi/full/10.1177/0003489419837993
DOI
10.1177/0003489419837993
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Huhn(김성헌)
Nam, Gi-Sung(남기성)
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0001-9493-3458
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173099
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