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A Case of Immunoglobulin A Pemphigus: Intraepidermal Neutrophilic Dermatosis Type

Authors
 Ji Hye Heo  ;  Hee Seong Yoon  ;  Si Hyub Lee  ;  Seung Dohn Yeom  ;  Lucia Kim  ;  Soo-chan Kim  ;  Ji Won Byun  ;  Jeonghyun Shin  ;  Gwang Seong Choi 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.57(8) : 492-495, 2019 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
ISSN
 0494-4739 
Issue Date
2019
Keywords
IgA pemphigus ; Intercellular IgA dermatosis ; Intraepidermal neutrophilic IgA dermatosis ; Subcorneal pustular dermatosis
Abstract
Immunoglobulin A (IgA) pemphigus is a rare variant of an autoimmune bullous disease with IgA antibodies. IgA pemphigus is divided into 2 major subtypes: the subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic (IEN) dermatosis type. We documented a case of an 18-year-old woman with recurrent generalized blisters and pustules that were especially severe in the intertriginous areas. Some half-and-half blisters and coalesced pustules in an annular pattern with crusts were simultaneously observed. A biopsy specimen from one of the halfand- half blister lesions showed intraepidermal separation with multiple neutrophils. Direct immunofluorescence staining revealed lace-like intercellular deposition of IgA in the entire epidermis. IgA antibody deposits were also observed in the patient's serum. The eruptions cleared with systemic steroids and colchicine 0.6 mg for 1 week, and the patient remained in partial remission at the 8-month follow-up. Herein, we report a case of IEN-type IgA pemphigus, clinically mimicking SPD with half-and-half blisters.
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3700594
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173082
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