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Perioperative implication of the endothelial glycocalyx

Authors
 Jong Wook Song  ;  Michael S. Goligorsky 
Citation
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.71(2) : 92-102, 2018 
Journal Title
 KOREAN JOURNAL OF ANESTHESIOLOGY 
ISSN
 2005-6419 
Issue Date
2018
Keywords
Endothelial glycocalyx ; Mechanotransduction ; Permeability ; Sulodexide
Abstract
The endothelial glycocalyx (EG) is a gel-like layer lining the luminal surface of healthy vascular endothelium. Recently, the EG has gained extensive interest as a crucial regulator of endothelial funtction, including vascular permeability, mechanotransduction, and the interaction between endothelial and circulating blood cells. The EG is degraded by various enzymes and reactive oxygen species upon pro-inflammatory stimulus. Ischemia-reperfusion injury, oxidative stress, hypervolemia, and systemic inflammatory response are responsible for perioperative EG degradation. Perioperative damage of the EG has also been demonstrated, especially in cardiac surgery. However, the protection of the EG and its association with perioperative morbidity needs to be elucidated in future studies. In this review, the present knowledge about EG and its perioperative implication is discussed from an anesthesiologist's perspective.
Files in This Item:
T201806195.pdf Download
DOI
10.4097/kjae.2018.71.2.92
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173002
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