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Endothelial glycocalyx-the battleground for complications of sepsis and kidney injury

Authors
 Jong Wook Song  ;  Joseph Zullo  ;  Mark Lipphardt  ;  Matthew Dragovich  ;  Frank X Zhang  ;  Bingmei Fu  ;  Michael S Goligorsky 
Citation
 NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.33(2) : 203-211, 2018 
Journal Title
 NEPHROLOGY DIALYSIS TRANSPLANTATION 
ISSN
 0931-0509 
Issue Date
2018
Keywords
endothelium ; endotoxemia ; lysosome ; sulodexide
Abstract
After briefly discussing endothelial glycocalyx and its role in vascular physiology and renal disease, this overview focuses on its degradation very early in the course of microbial sepsis. We describe our recently proposed mechanism for glycocalyx degradation induced by exocytosis of lysosome-related organelles and release of their cargo. Notably, an intermediate in nitric oxide synthesis, NG-hydroxy-l-arginine, shows efficacy in curtailing exocytosis of these organelles and improvement in animal survival. These data not only depict a novel mechanism responsible for very early glycocalyx degradation, but may also outline a potential preventive therapy. The second issue discussed in this article is related to the therapeutic acceleration of restoration of already degraded endothelial glycocalyx. Here, using as an example our recent findings obtained with sulodexide, we illustrate the importance of the expedited repair of degraded endothelial glycocalyx for the survival of animals with severe sepsis. These two focal points of the review on glycocalyx may not only have broader disease applicability, but they may also provide additional evidence to buttress the idea of the importance of endothelial glycocalyx and its maintenance and repair in the prevention and treatment of an array of renal and nonrenal diseases.
Files in This Item:
T201806192.pdf Download
DOI
10.1093/ndt/gfx076
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172983
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