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The infusion rate of mivacurium or atracurium for cesarean section compared with gynecological procedures

 Jong Hoon Kim  ;  Keong Tae Min  ;  Eun Kyoung Ahn  ;  Kun Ho Kim  ;  Yang Sik Shin 
 YONSEI MEDICAL JOURNAL, Vol.40(4) : 371-376, 1999 
Journal Title
Issue Date
Adult ; Atracurium/administration & dosage* ; Atracurium/therapeutic use ; Cesarean Section* ; Female ; Humans ; Injections, Intramuscular ; Isoquinolines/administration & dosage* ; Isoquinolines/therapeutic use ; Mivacurium ; Neuromuscular Nondepolarizing Agents/administration & dosage* ; Neuromuscular Nondepolarizing Agents/therapeutic use ; Pregnancy
Mivacurium is mainly metabolized by plasma cholinesterase, whereas atracurium is removed by Hofman elimination. The purpose of this study was to compare the infusion rate of atracurium and mivacurium in maintaining surgical relaxation, and to compare their recovery indices between parturients and non-pregnant women. Muscle relaxation was maintained by the continuous infusion of relaxants to retain the first response of train-of-four (TOF) at 5% of control. When mivacurium was used, Bolus-T5 (duration from the end of mivacurium bolus injection to 5% single twitch recovery) was measured. After discontinuing the infusion, the recovery index was measured. The infusion rate of mivacurium, not atracurium, was significantly lower in parturients and Bolus-T5 of parturients was significantly longer than that of non-pregnant women. There was no significant difference in the recovery indices of both relaxants. The authors concluded that the infusion rate of mivacurium in maintaining muscle relaxation in parturients should be reduced compared to the rate in non-pregnant women and measuring Bolus-T5 may be helpful in determining the infusion rate to maintain muscle relaxation.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
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