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Adenoid cystic carcinoma of the maxillary antrum

 Gwi Eon Kim  ;  Hee Chul Park  ;  Ki Chang Keum  ;  Chang Geol Lee  ;  Chang Ok Suh  ;  Won Joo Hur  ;  Kwang Moon Kim  ;  Won Pyo Hong 
 American Journal of Otolaryngology, Vol.20(2) : 77-84, 1999 
Journal Title
 American Journal of Otolaryngology 
Issue Date
Adult ; Aged ; Carcinoma, Adenoid Cystic/mortality ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Adenoid Cystic/therapy* ; Female ; Humans ; Male ; Maxillary Sinus Neoplasms/mortality ; Maxillary Sinus Neoplasms/pathology ; Maxillary Sinus Neoplasms/therapy* ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
PURPOSE: To investigate characteristic clinical features and outcome for patients with adenoid cystic carcinoma (ACC) of the maxillary antrum. PATIENTS AND METHODS: Twenty-two patients with ACC of the maxillary antrum were initially treated with surgery alone (3 patients), radiation alone (9 patients), or a combination of surgery and radiation (10 patients). Salvage treatment for initial failure was individualized. Patterns of failure, survival, and prognostic factors were retrospectively analyzed. RESULTS: The most frequent site of failure was local recurrence at the primary site (72.7%). All patients treated with either surgery alone or radiation alone experienced one or more local recurrences, whereas patients who received planned combined surgery and radiation had a much lower local recurrence rate (40%). Neck node failure (4.6%) was an uncommon event, whereas distant metastases were clinically documented in seven patients (32%). Most of the treatment failures appeared within 5 years, but treatment failures after 5 years were not uncommon. The overall survival and disease-free survival rates at 10 years were 37.6% and 13.6%, respectively. Clinicopathological factors, such as location of primary tumor, tumor stage, and histological grade were of no value in predicting a favorable survival. The significant prognostic factors influencing 10-year survival were the pathological finding of perineural invasion and the initial mode of treatment. CONCLUSION: ACC of the maxillary antrum represented a unique natural history characterized by a more aggressive tumor behavior and an unfavorable prognosis. Combined surgery and radiotherapy is recommended for optimal local control and survival.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
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