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아토피 피부염 환아에서 두피의 비듬내 집먼지진드기 항원 농도와 임상증상 사이의 상관관계

Authors
 류정우  ;  염혜영  ;  전숙영  ;  이기영  ;  정병주  ;  김규언 
Citation
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.9(1) : 32-40, 1999 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
ISSN
 1225-679X 
Issue Date
1999
Keywords
Atopic dermatitis ; house dust mite
Abstract
Purpose: There are compelling evidences that house dust mites are important in the pathogenesis of atopic dermatitis. Recently, detection of house dust mite allergens from clothing, skin, and dust from human hair has been reported. To evaluate the importance of house dust mite exposure in the clinical severity of atopic dermatitis. Methods : We measured house dust mite allergens(Der f1 from Dermatophagoides farinae and Der p1 from D. pteronyssinus) in scalp dander from 27 children with atopic dermatitis and 41 children with asthma only by enzyme-linked immunosorbent assay and examined correlation between house dust mite allergen concentrations in scalp dander and clinical severity of atopic dermatitis in children. Results : Der f1 was detectable in scalp dander samples of 32 patients(47%) from overall 68 patient and Der p1 was detectable in 33 patients(49%). House dust mite allergens(Der f1 or Der p1) were detectable in scalp dander samples of 46 patients (70%) from overall 68 patient. There was no significant differences in house dust mite allergen levels between atopic dermatitis patients and patients with asthma only. There was a tendency of inverse correlation between frequency of scalp washing and concentration of Der f1 in scalp dander extract(r=-0.24, P=0.052). There was a significant correlation between severity grade of atopic dermatitis and concentration of Der f1 in scalp dander(r=0.39, P<0.05) in 27 children with atopic dermatitis. However, there was no significant correlation between severity grade of atopic dermatitis and concentration of Der p1 in scalp dander(r=-0.05, P>0.05). Conclusion : There was a significant correlation between house dust mite allergen concentrations in scalp dander and clinical severity in children with atopic dermatitis. And these results suggest that exposure to house dust mite allergen is important in the pathogenesis of atopic dermatitis.
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=1923215
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172853
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