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우리나라에 서식하고 있는 모기(Culex pipiens )의 항원 추출과 항원성 분석

Other Titles
 Immunoblot Analysis of Allergens in Mosquito , Culex pipiens 
 이기영  ;  이기선  ;  이수영  ;  정병주  ;  김규언  ;  류정우  ;  염혜영  ;  이한일  ;  용태순  ;  전성후 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.9(3) : 252-258, 1999 
Journal Title
Pediatric Allergy and Respiratory Disease(소아알레르기 호흡기학회지)
Issue Date
Mosquito ; Immunoblot
Purpose : Adverse reactions to mosquito bites have been recognized for some time, and these usually consist of large swellings, generalized urticaria, angioedema, and less frequently asthma. There have been some efforts to define immunologic characteristics of mosquito allergens throughout the world. But, in Korea, the immunologic analysis of mosquito allergen have not been made. Methods : Extracts of locally distributed female mosquito Culex pipiens, were prepared from their heads and thoraxes. By sodium dodecylsulfate-polyacrylamide gel electrophoresis, proteins of two extracts were isolated. Then their proein bands were transferred to nitrocellulose membrane. Immunoblotting was performed with sera of allergic patients to mosquito bites, then completed by antibodies to human IgE. Results : Immunoblotting showed IgE binding proteins weighing 70 kD, 60 kD, 34 kD in Culex pipiens. Conclusion : We found that mosquito antigens induced IgE response, and it suggested that species-specific antigens exist. Further investigation using salivary gland extracts from Culex genus are needed in identifying specific allergens.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
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