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관상동맥질환에서 응고인자 VII의 활성도와 R353Q 유전자 다형성

Other Titles
 Coagulation Factor VII Activity and R353Q Polymorphism in Coronary Artery Disease 
 김현경  ;  송경순  ;  박규은  ;  성주연  ;  박영숙  ;  심원흠  ;  지선하 
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.19(5) : 486-490, 1999 
Journal Title
Korean Journal of Clinical Pathology(대한임상병리학회지)
Issue Date
Factor VII ; R353Q polymorphism ; Coronary artery disease
Background :High plasma levels of coagulation factor VII (FVII) are associated with a risk of coronary artery disease (CAD). Plasma FVII levels are influenced by environmental and genetic factors. We investigated whether the risk of CAD is associated with R353Q polymorphism and whether this polymorphism is associated with factor VII activity. Method :We analysed plasma levels of FVII:C and FVII genotype for R353Q polymorphism in 85 CAD patients, 63 healthy controls, and 27 patient controls. Total cholesterol, HDL-cholesterol and triglyceride were also measured in the same study population. Result :There were no differences among CAD patients, healthy, and patient controls in plasma levels of FVII:C. Allele Q of the R353Q polymorphism was less frequent in CAD patients (11.8%) than healthy controls (17.5%), although the difference was not statistically significant. Patients with the RQ genotype had a decreased risk of CAD (odds ratio, 0.29). There was no association between R353Q polymorphism and plasma levels of FVII:C. Plasma levels of FVII:C were positively correlated with total cholesterol and triglyceride. Conclusion :Our findings suggest that R353Q polymorphism may confer significant protection from CAD and that plasma levels of FVII:C may be influenced by total cholesterol and triglyceride.
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Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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