아토피피부염 환자에서 집먼지진드기 항원 - 자가항체 면역 복합체 치료효과

Abstract

Background: Exposure to airborne allergens exacerbates symptoms of atopic dermatitis in sen- sitive patients. Objective : We attempted to evaluate the therapeutic effect of Dermatophagoides farinae anti- gen-autoantibody immune complex therapy in atopic dermatitis. Methods : Four patients with atopic dermatitis were treated with antigen-autoantibody im- mune complex therapy using D. farinae antigen for 1 year. The therapeutic effect was evaluated by clinical severity (erythema, excoriations, scale, pruritus, lichenification) and D. farinae specif- ic antibodies, skin test to D. farinae, total IgE, eosinophil count and soluble vascular cell adhesi- on molecule-1 (VCAM-1). Results : One of four patients had significant improvement in clinical severity and decrease in serum eosinophil count, but three of four patients had no significant improvement in clinical se- verity, skin test to D. farinae, total IgE, specific antibodies and soluble VCAM-1 after allergen- antibody complex therapy except specific IgE to D. farinae. Conclusion : The efficacy of allergen-antibody complex therapy may be limited in some atopic dermatitis patients.