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아토피피부염 환자에서 집먼지진드기 항원 - 자가항체 면역 복합체 치료효과

Other Titles
 Therapeutic effect of Dermatophagoides farinae antigen - autoantibody immune complex therapy in atopic dermatitis 
Authors
 이광훈  ;  최현주  ;  최유진  ;  김수민  ;  박중원  ;  홍천수 
Citation
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.19(6) : 942-951, 1999 
Journal Title
Journal of Asthma, Allergy and Clinical Immunology(천식 및 알레르기)
ISSN
 1226-8739 
Issue Date
1999
Keywords
atopic dermatitis ; Dermatophagoides farinae ; allergen-antibody complex therapy
Abstract
Background: Exposure to airborne allergens exacerbates symptoms of atopic dermatitis in sen- sitive patients. Objective : We attempted to evaluate the therapeutic effect of Dermatophagoides farinae anti- gen-autoantibody immune complex therapy in atopic dermatitis. Methods : Four patients with atopic dermatitis were treated with antigen-autoantibody im- mune complex therapy using D. farinae antigen for 1 year. The therapeutic effect was evaluated by clinical severity (erythema, excoriations, scale, pruritus, lichenification) and D. farinae specif- ic antibodies, skin test to D. farinae, total IgE, eosinophil count and soluble vascular cell adhesi- on molecule-1 (VCAM-1). Results : One of four patients had significant improvement in clinical severity and decrease in serum eosinophil count, but three of four patients had no significant improvement in clinical se- verity, skin test to D. farinae, total IgE, specific antibodies and soluble VCAM-1 after allergen- antibody complex therapy except specific IgE to D. farinae. Conclusion : The efficacy of allergen-antibody complex therapy may be limited in some atopic dermatitis patients.
Files in This Item:
T199902555.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172813
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