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위장관 증상으로 내원한 특발성 단독성 부신피질 자극호르몬 결핍 1 예

Other Titles
 A Case of Isolated Adrenocorticotropic Hormone Deficiency Presenting with Gastrointestinal Symptoms 
 김진석  ;  송영득  ;  서정훈  ;  남재현  ;  박석원  ;  이용찬  ;  임승길  ;  김경래  ;  이현철  ;  허갑범  ;  박인서 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.33(1) : 129-134, 1999 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Isolated ACTH deficiency
Isolated ACTH (adrenocorticotropic hormone) deficiency is a rare cause of secondary adrenocortical insufficiency. The clinical features of secondary adrenal insufficiency differ from those of primary adrenocortical insufficiency in that pituitary secretion of ACTH and -lipotropin is deficient and thus hypersegmentation is not present. Prominent features are weakness, lethargy, easy fatigability, anorexia, nausea, and occasionally vomiting. Volume depletion, dehydration, and electrolyte abnormalities are rarely observed. Usually, hypotension is not present except in acute presentations Recently, we experienced a 48-year- old woman admitted because of nausea, vomiting, and diarrhea The level of basal plasma cortisol was low, and the level of plasma ACTH and cortisol decreased responding to combined pituitary stimulation test. Plasma ACTH concentration remained low even after intravenous injection of corticotropin releasing factor. It suggested that the defect of ACTH secretion was apparently due to intrinsic pituitary dysfunction rather than hypothalamic disease. Brain magnetic resonance imaging failed to reveal any radiological abnormalities of the sellar or suprasellar area.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyun Chul(이현철)
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