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Role of definitive radiation therapy for larynx preservation in patients with advanced laryngeal cancer

 Ki Chang Keum  ;  Gwi Eon Kim  ;  Chang Ok Suh  ;  Jong Young Lee  ;  Jae Kyung Roh  ;  Kwang Moon Kim  ;  Young Ho Kim  ;  Won Pyo Hong 
 Journal of Otolaryngology, Vol.28(5) : 245-251, 1999 
Journal Title
 Journal of Otolaryngology 
Issue Date
Adult ; Aged ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/radiotherapy* ; Chemotherapy, Adjuvant ; Chi-Square Distribution ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Laryngeal Neoplasms/drug therapy ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/radiotherapy* ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Survival Rate ; Treatment Outcome
OBJECTIVE: Recently, neoadjuvant chemotherapy (CT) and radiation therapy (RT) have been advocated as a standard treatment for laryngeal preservation in patients with locally advanced laryngeal cancer. However, it is still being debated whether adding neoadjuvant CT to conventional RT makes an effective contribution to laryngeal preservation. The current study was designed to resolve this controversy. DESIGN: Retrospective clinical study. SETTING: The Severance Hospital, Yonsei Cancer Center, Yonsei University, Seoul, Korea. METHOD: Eighty patients (stages III, IV) with squamous cell carcinoma of the larynx were divided into two groups according to treatment modalities, which consisted of RT alone (N = 40, Group 1) and neoadjuvant CT plus RT (N = 40, Group 2). Comparative analysis was undertaken to investigate the differences in the organ preservation rate and treatment results between the two groups. RESULTS: There was no significant difference in the response rate and patterns of treatment failure between the two groups. The 5-year survival rate was similar between Group 1 (24%) and Group 2 (31%) (p = .1556). In addition, the larynx was almost equally preserved in Group 1 (62%) versus Group 2 (63%). CONCLUSIONS: Radiation therapy without neoadjuvant CT seems to be a valid alternative treatment for the purpose of laryngeal preservation in locally advanced laryngeal cancer.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Young Ho(김영호)
Roh, Jae Kyung(노재경)
Suh, Chang Ok(서창옥)
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