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Sinus histiocytosis (Rosai-Dorfman disease) clinically limited to the skin.

 Jin Moon Kang  ;  Woo Ick Yang  ;  Soo Min Kim  ;  Min-Geol Lee 
 Acta Dermato-Venereologica, Vol.79(5) : 363-365, 1999 
Journal Title
 Acta Dermato-Venereologica 
Issue Date
Adult ; Antigens, CD/analysis ; Antigens, Differentiation, Myelomonocytic/analysis ; Biopsy ; Cheek ; Diagnosis, Differential ; Facial Dermatoses/diagnosis* ; Facial Dermatoses/pathology ; Histiocytes/chemistry ; Histiocytes/pathology ; Histiocytosis, Sinus/diagnosis* ; Histiocytosis, Sinus/pathology ; Humans ; Immunohistochemistry ; Male ; S100 Proteins/analysis ; Skin/pathology
Sinus histiocytosis with massive lymphadenopathy (SHML) is an idiopathic proliferation of unique histiocytes that have vesicular nuclei and voluminous pale cytoplasm, often with emperipolesis. Pure cutaneous involvement is very rare. We describe a patient with SHML limited to the skin whose lesion has spontaneously regressed. A 35-year-old Korean male visited the Department of Dermatology due to facial rash for 2 months. A 3 x 3.5 cm-sized well-demarcated dark erythematous nontender plaque was noted on the right cheek. Skin biopsy showed dense, nodular infiltrates of histiocytes with abundant cytoplasm and vesicular nuclei rimmed by lymphoplasma cell aggregates throughout the upper and mid-dermis. The histiocytes were immunohistochemically positive for S-100 protein and CD68, but negative for CD1a. Laboratory tests and a thorough physical examination revealed no abnormalities. These findings suggested that this was a case of SHML clinically limited to the skin. The skin lesion was initially resistant to steroid therapy, but began to regress 10 months after the onset without further treatment.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
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