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Helicobacter pylori 감염증 치료에서 Omeprazole 사제요법의 박멸 효과

Other Titles
 Effect of Omeprazole Quadruple Therapy on Eradication of Helicobacter pylori 
Authors
 유효민  ;  이용찬  ;  이상인  ;  문영명  ;  강진경  ;  박인서 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.33(4) : 473-481, 1999 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
1999
Keywords
Helicobacter pylori ; Quadruple regimen ; Retreatment
Abstract
Background/Aims: The optimal regimen for the eradication of H. pylori remains unclear. Thus the authors evaluated the effect of one-week course of omeprazole quadruple regimen on eradication o H. pylori in Korea. Methods: We investigated the outcome of quadruple therapy on eradication o H. pylori in 93 patients with H. pylori positive gastritis or peptic ulcer diseases. We tried three different quadruple regimens. were A quadruple regimen (OBMA) including omeprazole 20 mg b.i.d.amoxicillin 1 g b.i.d., metronidazole 500 mg t.i.d. and bismuth 240 mg b.i.d. was used for 64 pati ents. Another regimen (OABC) including omeprazole 20 mg b.i.d., amoxicillin 500 mg t.i.d., bismuth 240 mg b.i.d. and clarithromycin 250 mg b.i.d. was used for 18 patients and the third regimen (OAMC) including omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., metronidazole 500 mg t.i.d. and clarithromycin 250 mg b.i.d. (OAMC) was applied for 11 patients. Results: The overall eradication rate of quadruple regimens was 84.9%. Eradication rates of each regimen were 94.4% in OABC 81.9% in OAMC and 82.8% in OBMA. Eradication was successful in 85.2% of 61 patients who used quadruple regimen as first line treatment and in 84.4% of 32 patients who used quadruple regimen for retreatment. The side effects were observed in 16.1% of the patients and the compliance rate wa 98.9%. Conclusions: One-week course of quadruple regimens was effective in the eradication of H pylori and showed good compliance. Quadruple regimen was also effective in patients who failed to eradicate H. pylori with dual or triple regimen.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172689
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