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Helicobacter pylori 감염증 치료에 실패한 환자의 임상상과 항생제 내성

Other Titles
 Clinical Characteristics of Patients with Failed Eradication of Helicobacter pylori and Antibiotic Resistance 
 유효민  ;  이용찬  ;  박효진  ;  김원호  ;  이경원  ;  ·박인서 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.33(3) : 311-320, 1999 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Helicobacter pylori ; Failed eradication ; Antibiotic resistance
Background/Aims: The decisive factors influencing the eradication of H. pylori still remain unclear To identify such factors, we investigated the clinical characteristics and antibiotic resistance of patients. Methods: Patients with H. pylori infection were treated with dual or triple regimens. Eradi cation rates were analyzed on the basis of clinical factors, endoscopic factors and antibiotic resistance Results: Sixty-three H. pylori infected patients were enrolled (mean age 49.4). The eradication rate was significantly higher in compliant patients (71.9%) than in non-compliant patients (20%). Other clinical and endoscopic factors did not significantly influence the outcome of treatment. In 42 isolated strains, metronidazole resistance (MIC>8 μg/mL) was observed in 35.7% of the strains and clari thromycin resistance (MIC>2 μg/mL) was observed in 7.1%. The eradication rate in metronidazole resistant strains was 55.5%, which was lower than that in metronidazole sensitive strains (78.6%) The median value of metronidazole MIC in the group of successful eradication (0.94 μg/mL) was significantly lower than that in the group of failed eradication (64.0 μg/mL). Conclusions: Patient' s compliance for regimens seems to be the most important factor which affect H. pylori eradication Metronidazole resistance which is highly prevalent in our population may influence the efficacy of anti-H. pylori treatment regimen containing metronidazole.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
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