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Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants

Authors
 Young Mo Sohn  ;  Min Soo Park  ;  Hye Ok Rho  ;  Laura J Chandler  ;  Robert E Shope  ;  Theodore F Tsai 
Citation
 VACCINE, Vol.17(18) : 2259-2264, 1999 
Journal Title
VACCINE
ISSN
 0264-410X 
Issue Date
1999
MeSH
Antibodies, Viral/biosynthesis ; Child, Preschool ; Encephalitis Viruses, Japanese/immunology* ; Encephalitis, Arbovirus/immunology* ; Encephalitis, Arbovirus/prevention & control ; Humans ; Immunization, Secondary*/adverse effects ; Immunoglobulin M/blood ; Infant ; Vaccines, Attenuated/adverse effects ; Vaccines, Attenuated/immunology ; Vaccines, Inactivated/adverse effects ; Vaccines, Inactivated/immunology ; Viral Vaccines/adverse effects ; Viral Vaccines/immunology*
Abstract
Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988 and recently, licensure of the vaccine in Korea has been sought. In the first clinical evaluation of the vaccine outside of China, we monitored side effects in 84 children and evaluated antibody responses to a single dose given as primary JE vaccination in 68 children, 1-3 years old (mean age 27 months). No significant adverse events were noted. Neutralizing antibodies (geometric mean titer [GMT] of 188) were produced in 96% of the 68 subjects. In 10 other children who previously had been immunized with two or three doses of inactivated JE vaccine, the booster administration of SA14-14-2 vaccine produced an anamnestic response in all, with a GMT of 3378. In a comparison group of 25 children previously immunized with two doses of inactivated vaccine, neutralizing antibody titers were detected in 16 (64%). Viral specific IgM was detected in nine primary vaccinees (13%) but in others, IgM may have declined to undetectable levels in the four week postimmunization sample. Live attenuated SA14-14-2 JE vaccine is a promising alternative to the only commercially available JE vaccine for national childhood immunization programs in Asia
Full Text
https://www.sciencedirect.com/science/article/pii/S0264410X99000067
DOI
10.1016/s0264-410x(99)00006-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172608
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