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대도시의 입자상 물질이 A549와 RAW264.7 세포에 미치는 영향

Other Titles
 Effects of Particulate Matters on A549 and RAW 264.7 Cells 
 박영만  ;  김지홍  ;  김경아  ;  노철언  ;  김형중  ;  임영 
 Korean Journal of Preventive Medicine (예방의학회지), Vol.34(1) : 41-46, 2000 
Journal Title
Korean Journal of Preventive Medicine(예방의학회지)
Issue Date
Environmental pollution ; Epithelial cells ; Macrophages
Objectives : To investigate the effects of particulate matter (PM), a marker of environmental pollution derived from combustion sources, on lung epithelial cells (A549) and macrophage (RAW 264.7). Methods : The production of reactive radicals from lung cells, the lipid peroxidation of cell membrane, and the cytotoxicity of PM were measured using an in vitro model. The results were compared with a control group. Results : The presence of PM significantly increased the production of reactive oxygen species and reactive nitrogen species with time and in a dose dependent pattern and also increased the malondialdehyde concentration in lung epithelial cells. The cytotoxicity of PM was increased with increasing concentration of PM. Conclusions : It has been suggested that urban particulate matter causes an inflammatory reaction in lung tissue through the production of hydroxyl radicals, nitric oxides and numerous cytokines. The causal chemical determinant responsible for these biologic effects are not well understood, but the bioavailable metal in PM seems to determine the tonicity of inhaled PM.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
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