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전국 12개 병원 환자에서 분리된 Extended-Spectrum β-Lactamase 생성 Escherichia coli와 Klebsiella pneumoniae

Other Titles
 Characterization and prevalence of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from 12 Korean hospitals 
 송원근  ;  이경원  ;  김선주  ;  정석훈  ;  장철훈  ;  신혜정  ;  조성란  ;  안지영  ;  어영  ;  신종희  ;  이혜수  ;  홍성근  ;  용동은  ;  정윤섭 
 Journal of the Korean Society for Chemotherapy (대한화학요법학회지), Vol.18(4) : 401-410, 2000 
Journal Title
 Journal of the Korean Society for Chemotherapy (대한화학요법학회지) 
Issue Date
Extended-spectrum β-lactamase(ESBL) ; Escherichia coli ; Klebsiella pneumoniae ; Korean hospitals
Background : Presence of extended spectrum β-lactamase (ESBL) -producing gram-negative bacilli have been reported in Korea, but our understanding of the prevalence is limited. The aim of this study was to determine the nationwide prevalence and antimicrobial susceptibility of ESBL -producing Escherichia coli and Klebsiella pneumoniae, and to characterize the patients and sources. Methods: A total of 1.171 E. coli and 585 K. pneumoniae non-duplicate isolates were collected from 12 hospitals in September to December 1999. ESBL production was determined by National Committee for Clinical Laboratory Standards methods using cefpodoxime, cefotaxime, ceftazidime, and aztreonam disk. Positive double disk synergy tests were considered ESBL producers. Results : ESBL-producing E. coli and K. pneumoniae isolates were detected from all 12 hospitals. The proportion of ESBL-producers was 9.8% (3.5-19.6%) of the E. coli and 25.6% (10-41.3%) of the K.. pneumoniae isolates. The common source of ESBL-producers was sputum (27.4%) and patients in intensive care unit (31.7%). ESBL-producing isolates were more often resistant to aminoglycosides and cotrimoxazole. Conclusion : ESBL-producing E. coliand K.. pneumoniae are widespread to all levels of Korean hospitals. ESBL-producers are more prevalent among isolates from urine and sputum and from intensive care unit patients. These organisms are more often resistant than the non- ESBL -producers to amjnoglycosides and cotrimoxazole.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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