0 63

Cited 0 times in

납이 뇌줄기 청색반점핵의 norepinephrine 함유 신경세포에 미치는 영향

DC FieldValueLanguage
dc.contributor.author박경아-
dc.contributor.author이원택-
dc.contributor.author이종은-
dc.date.accessioned2019-11-11T06:18:24Z-
dc.date.available2019-11-11T06:18:24Z-
dc.date.issued2000-
dc.identifier.issn1225-1305-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/172421-
dc.description.abstractThe neurotoxic effects of inorganic lead, a common environmental toxic substance, include peripheral neuropathy in adults and encephalopathy in children. Behavioral changes including hyperactivity, short attention span, easy distractibility and impulsiveness have also been noted in patients with chronic lead exposure in childhood. The level of norepinephrine in brain may relate to hyperactivity and chronic lead exposure. The purpose of this study was to determine the effect of inorganic lead (PbCl(2)) administration in neonatal rats using immunocytochemical and electron microscopical analysis of norepinephrinergic neurons of the locus ceruleus. Lead chloride were dissolved in distilled water at the concentration of 0.05%, 0.1% and 0.2% and the solution was administered orally via drinking water. After 4, 8 or 12 weeks of continuous administration, all rats were sacrificed and the brain was processed and immunostained with antibody against tyrosine hydroxylase, a rate limiting enzyme of norepinephrine synthesis antibody. The number of tyrosine hydroxylase immunostained cell bodies in locus ceruleus was estimated. Densitometric analysis of tyrosine hydroxylase immunoreactive profiles in electron microscopic photographs were done by using image analyzer. The number of tyrosine hydroxylase immunoreactive neurons in the locus ceruleus had increased statistically after lead administration. Density of tyrosine hydroxylase immunoreactive profiles in the electron microscopy had also increased. Degenerative changes, such as intra-axonal vacuolar space formation, were found within tyrosine hydroxylase immunoreactive axons. Somewhat widened intercellular spaces and retracted processes were also found in the region of the locus ceruleus. Increased tyrosine hydroxylase immunoreactivity may correlate with hyperreactivity of lead intoxicated children. Degenerative changes may be responsible for the short attention span, easy distractibility and impulsiveness observed in case of mild lead poisoning.-
dc.description.statementOfResponsibilityrestriction-
dc.languageKorean-
dc.publisher대한해부학회-
dc.relation.isPartOfKorean Journal of Anatomy (대한해부학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title납이 뇌줄기 청색반점핵의 norepinephrine 함유 신경세포에 미치는 영향-
dc.title.alternativeThe Effects of Chronic Lead Exposure on Norepinephrinergic Neurons of the Nucleus Locus Ceruleus of the Rat-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthor이원택-
dc.contributor.googleauthor윤호-
dc.contributor.googleauthor이동주-
dc.contributor.googleauthor이종은-
dc.contributor.googleauthor구철회-
dc.contributor.googleauthor박경아-
dc.contributor.localIdA01424-
dc.contributor.localIdA03007-
dc.contributor.localIdA03007-
dc.contributor.localIdA03146-
dc.contributor.localIdA03146-
dc.relation.journalcodeJ01961-
dc.identifier.urlhttp://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022980907-
dc.subject.keywordTYROSINE HYDROXYLASE-
dc.subject.keywordNOREPINEPHRINE-
dc.subject.keywordInorganic lead-
dc.subject.keywordLocus ceruleus-
dc.subject.keywordImmunohistochemistry-
dc.contributor.alternativeNamePark, Kyung Ah-
dc.contributor.affiliatedAuthor박경아-
dc.contributor.affiliatedAuthor이원택-
dc.contributor.affiliatedAuthor이원택-
dc.contributor.affiliatedAuthor이종은-
dc.contributor.affiliatedAuthor이종은-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage423-
dc.citation.endPage432-
dc.identifier.bibliographicCitationKorean Journal of Anatomy (대한해부학회지), Vol.33(4) : 423-432, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.