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한국인에서 경도 및 중등도의 여드름에 대한 경구 Isotretinoin의 유효성 및 안전성 평가

Other Titles
 The Efficacy and Safety of Isotretinoin in Korean Patients with Mild to Moderate Acne 
 최응호  ;  황상민  ;  서대헌  ;  성경제  ;  이승헌 
 Korean Journal of Dermatology (대한피부과학회지), Vol.38(10) : 1309-1314, 2000 
Journal Title
 Korean Journal of Dermatology (대한피부과학회지) 
Issue Date
ISOTRETINOIN ; Acne vulgaris ; Korean ; Efficacy ; Safety
Background:Oral isotretinoin has been widely used in severe acne patients and is known as a very effective drug. Recently it is being used in any grades and any types of acne. However we have few reports of clinical study about oral isotretinoin in our country. Objective:To investigate clinical efficacy, factors influencing the result and side effects of oral isotretinoin in mild to moderate acne patients in Korea, prospectively. Materials and methods:The patients with mild to moderate acne visiting out-patient dermatology clinics of four university hospitals have taken oral isotretinoin 0.3-1.0mg/kg/day over 16 weeks. The clinical improvement was assessed by the scores using photographs before treatment and at 8 weeks, 12 weeks, 16 weeks, 20 weeks after treatment, and by the satisfaction of patients and physicians at the end of treatment. The side effects were recorded and SGOT, SGPT, cholesterol and triglyceride were checked at regular intervals. Results:The grade of acne was much improved proportional to the duration of treatment. The factors showing better results were dosage and duration of oral isotretinoin, older age, more severe acne and severe acne in the past. About 90% of patients and physicians were satisfied with the result at the end of treatment. The side effects, mainly mucocutaneous symptoms were expectable and tolerable in the most cases. The values of SGOT, SGPT, cholesterol and triglyceride were increased after treatment but within normal reference range. Conclusion:Oral isotretinoin is a very effective agent in Korean patients with mild to moderate acne. We expect the better result in patients having high dose and long duration of oral isotretinoin, old ages and more severe acne. If we understand it's side effects enough, we can use it very safely. (Korean J Dermatol 2000;38(10): 1309~1314)
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
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