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제 2형 당뇨병 환자에서 알부민뇨와 심혈관계 질환의 유병률에 대한 연구

Other Titles
 Study on the Prevalence of Coronary Heart Disease and Albuminuria in Type 2 Diabetic Patients 
Authors
 강태수  ;  최소래  ;  김영아  ;  박홍수  ;  서정건  ;  황학진  ;  허애정  ;  윤세정  ;  신석균  ;  강신욱  ;  최규헌  ;  이호영  ;  한대석  ;  하성규 
Citation
 Korean Journal of Nephrology (대한신장학회지), Vol.19(5) : 891-898, 2000 
Journal Title
Korean Journal of Nephrology(대한신장학회지)
ISSN
 1225-0015 
Issue Date
2000
Keywords
Microallbuminuria ; Diabetic nephropathy ; Coronary heart disease ; Microalbuminuria
Abstract
There are opinions that microalbuminuria acts as an independent risk factor for cardiovascular diseases, related to other risk factors such as endothelial cell dysfunction, hypertension, insulin resistance, obesity, hyperlipidemia and platelet aggregation dysfunction in diabetic and non-diabetic patients. We examined the prevalence of microalbuminuria and macroalbuminuria and the relationship of microalburninuria and macroalbuminuria to coronary heart. disease in type 2 diabetic patients. Out of 798 t 2 diabetic patients who were hospitalized at Yonsei medical center from Oct. 1997 to Feb. 1999, we studied 181 patients who had normal renal function and were examined 24 hour urine albumin excretion. According to the amount of urine albumin excretion, 181 patients were categorized into three groups; normoalbuminuria(less than 30mg/24hour), microalbuminuria(30-300mg/24hour) and macroalbuminxia (more than 300mg/24hour). Patients were tested using treadmill test, stress thallium scan, echocardiography, and coronary angiography for the evaluation of coronary heart disease. The freguency of normoalburninuria, microalbuminuria, and macroalbuminuria in our patients were 50.3%(91/181), 30.9%(56/181), and 18.3%(34/181), respectively. In each group, the prevalence of hypertension were 42.5%, 78.5%, and 82.3%, respectively and the prevalence of cardiovascular disease were 24.7%, 50.0%, and 46.0%, respectively. Microalbuminuria and macroalbuminuria groups showed statistically significant differences in the prevalence of hypertension and coronary heart disease compared with normoalbuminmia group(p<0.05). In addition, the prevalence of diabetic retinopathy were 37.3%, 58.9%, and 55.8%, respectively and microalbuminuria and macroalbuminuria groups showed statistically significant differences in the prevalence of diabetic retinopathy compared with normoalbuminuria group(p<0.05). We conclude that microalbuminuria and macroalbuminuria is a strong predictor of coronary heart disease in patients with type 2 diabetes.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172233
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