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백서에서 삼차신경 유발전위의 특성과 경로분석

Other Titles
 Characteristics of Trigeminal Evoked Potential and It’s Pathway in the Rat 
 김세혁  ;  조춘식  ;  권오규  ;  이배환  ;  박용구  ;  정상섭 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.29(0) : 985-994, 2000 
Journal Title
Journal of Korean Neurosurgical Society(대한신경외과학회지)
Issue Date
Trigeminal evoked potential ; Rat ; Electrical stimulation ; Near-field potential
Objective:There are some advantages of trigeminal evoked potential(TEP) recording compared to other somatosensory evoked potential(SSEP) recordings. The trigeminal sensory pathway has a pure sensory nerve branch, a broader receptive field in cerebral cortex, and a shorter pathway. Despite these advantages, there is little agreement as to what constitutes a normal response and what wave forms truly characterize the intraoperative TEP. This study presents the normative data of TEP recorded on the epidural surface of the rat with a platinum ball electrode.
Materials & Methods:Under general anesthesia with urethane, the adult Sprague-Dawley male rats(300-350g) were given electrical stimulation with two stainless steel electrodes which were inserted into the subcutaneous layer of the area around whiskers. A reference electrode was positioned in the temporalis muscle ipsilateral to the recording site.
Results:TEPs were recorded in the Par I area of somatosensory cortex and recorded most apparently on the pointof 2mm posterior from the bregma and 6mm lateral from the midline. The typical wave form consisted of 5 peaks(N1-P1-N2-P2-N3 according to emerging order, upward negativity). Each latency to corresponding peaks was not influenced by the different intensities of stimulation, especially from 1 to 5mA. Average latencies of 5 peaks were in the following order;7.7, 11.1, 15, 22.3, 29.4ms. There was also no significant difference between latencies before and after administration of muscle relaxant(pancuronium). For the electrophysiological localization of recorded waves, the action potential of a single unit was recorded with glass microelectrode(filled with 2M NaCl, 3- 5MΩ) in the thalamus of rat. A sharp wave was recorded in the VPM nucleus, in which the latency was shorter than that of N1. This suggests that all 5 peaks were generated by neural activities in the suprathalamic pathway.
Conclusion:In terms of recording near-field potentials, our data also suggests that TEP in the rat may be superior to other SSEPs. In overall, these results may afford normative data for the studies of supratentorial lesions such as hydrocephalus or cerebral ischemia which can have an influence on near-field potentials.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
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