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Helicobacter pylori 감염 치료법에서 Lansoprazole과 Omeprazole의 효과 비교

Other Titles
 Comparison of Lansoprazole and Omeprazole in Therapy for Helicobacter pylori infection 
 신성관  ;  이용찬  ;  윤영훈  ;  나호균  ;  김도영  ;  문병수  ;  김원호  ;  전재윤  ;  문영명  ;  강진경  ;  박인서 
 Korean Journal of Gastroenterology, Vol.35(6) : 716-723, 2000 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
Issue Date
Helicobacter pylori ; Lansoprazole ; Omeprazole
Background/Aims: The effectiveness of curative therapy for Helicobacter pylori (H. pylori) infection may vary according to the eradication rate, side effects, and compliance of regimen. Lansoprazole, one of proton-pump inhibitor, has been claimed to have greater anti-H. pylori activity than that of omeprazole in vitro. However, there is no literature concerning the comparison of therapeutic efficacy of these two drugs in Korea. Thus, we investigated the efficacy of combination therapy with amoxicillin, metronidazole, and either lansoprazole or omeprazole. Methods: Eighty Patients with H. pylori infection were treated with one of four regimens: lansoprazole 30 mg UID, amoxicillin 1.0 g BID (LA); lansoprazole 30 mg UID, amoxicillin 1.0 g BID, metronidazole 250 mg TID (LAM); omeprazole 20 mg BID, amoxicillin 1.0 g BID (OA); omeprazole 20 mg BID, amoxicillin 1.0 g BID, metronidazole 250 mg TID (OAM), for 14 days. Results: The eradication rates were 33.3% in LA, 50.0% in OA, 76.5% in LAM and 83.3% in OAM. The most frequently observed side effect was diarrhea or loose stool. Conclusions: Low dose lansoprazole-based regimen showed comparable eradication rate, side effects and compliance, as compared with omeprazole-based regimen. Further study using lansoprazole at various doses may be needed to evaluate the efficacy of anti-H. pylori eradication regimens in Korea. (Kor J Gastroenterol 2000;35:716 - 723)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
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