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한국의 Helicobacter pylori 감염진단에서 새로운 상용 혈청학적 검사방법인 Genedia TM 과 기존의 상용검사방법과의 비교 검토

Other Titles
 A Comparison of Accuracy between A New Commercial ELISA Test, GenediaTM Test and Other Commercial ELISA Tests for Serological Diagnosis of Helicobacter pylori Infection in Korea 
 윤영훈  ;  신성관  ;  이용찬  ;  문병수  ;  전재윤  ;  문영명  ;  박인서 
 Korean Journal of Gastroenterology, Vol.36(1) : 20-28, 2000 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
Issue Date
Helicobacter pylori ; Korean H. pylori ; Serologic diagnosis ; ELISA test ; GenediaTM test
Background/Aims : A new commercial enzyme linked immunosorbent assay (ELISA) test using Korean Helicobacter pylori (H. pylori) as an antigen, GenediaTM test, was compared to other serologic tests for H. pylori infection. Methods: Among two hundred seventy three subjects, H. pylori-positive group was consisted of 132 patients (50 peptic ulcer diseases, 52 chronic gastritis, and 30 gastric cancers) and H. pylori-negative group was consisted of 141 patients (121 adults and 20 pediatric patients). Endoscopic antral biopsy specimens were obtained for microscopy and rapid urease test (CLOTM test). We also performed GenediaTM IgG, IgA ELISA, G.A.P IgG, IgA ELISA, and Cobas-core IgG EIA. H. pylori infection was defermined when H. pylori was detected histologically or the results of CLOTM tests were positive. Results : The sensitivities and specificities of the serologic tests were 96.2% and 46.1% in GenediaTM IgG, 91.7% and 52.5% in GenediaTM IgA, 81.8% and 46.8% in G.A.P IgG, 25.0% and 85.1% in G.A.P IgA, 96.9% and 38.6% in Cobas-core test, respectively. In H. pylori-negative pediatric patients, the specificity of the tests was 80% in GenediaTM IgG, 95% in GenediaTM IgA, 60% in G.A.P. IgG, 100% in G.A.P IgA, and 75% in Cobas-core test. Conclusions: In Korea, GenediaTM test was comparable or superior to general serologic tests used for diagnosing H. pylori infection. However, it is necessary to improve the specificity of the GenediaTM test. (Kor J Gastroenterol 2000;36:20 - 28)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
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