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염증성 장질환 환자에서 첫 진단시의 골밀도

Other Titles
 Bone mineral density in newly diagnosed patients with inflammatory bowel disease 
 백일현  ;  양석균  ;  김원호  ;  김영관  ;  김효종  ;  이상호  ;  동석호  ;  김병호  ;  이정일  ;  장영운  ;  장 린 
 Korean Journal of Gastroenterology, Vol.35(4) : 439-447, 2000 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
Issue Date
Inflammatory bowel disease ; Bone mineral density ; Osteopenia ; Crohn's disease ; Ulcerative colitis
Background/Aims: The decrease of bone mineral density (BMD) has been reported in Western patients with inflammatory bowel disease (IBD). However, its prevalence and pathophysiology in Asian population have never been studied. The aim of this study was to investigate the prevalence and mechanism of osteopenia in Korean patients with newly diagnosed IBD. Methods: We studied 14 patients with Crohn's disease (CD) and 25 patients with ulcerative colitis (UC), all of whom had never used corticosteroids. BMD was measured in the lumbar spines and the femur by dual-energy X-ray absorptiometry. Biochemical parameters of bone metabolism, such as osteocalcine, iPTH, active and inactive vitamin D, were measured. Results: Reduced BMD (Z score<-1) at the spine was observed in 36% of the patients and there was no significant difference in lumbar Z scores in the patients with CD and the patients with UC. There was no significant difference in nutritional status or biochemical parameters of bone metabolism between the patients with normal BMD and those with decreased BMD. There was a significant correlation between the lumbar BMD and femoral neck BMD. Conclusions: Decreased trabecular bone density is a common feature in Korean patients with newly diagnosed IBD as well as in Western patients. The mechanism causing low bone mass is not related to ethnic difference. Malnutrition such as calcium or vitamin deficiency could possibly play a certain role in the pathogenesis of bone loss in patients with newly diagnosed IBD. (Kor J Gastroenterol 2000;35:439 - 447)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
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