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40세 이하에서 발생한 원발성 간암의 임상상.

Other Titles
 Clinical Characteristics of Hepatocellular Carcinoma in Young People 
Authors
 한광협  ;  문희용  ;  최 원  ;  백용한  ;  이관식  ;  전재윤  ;  문영명 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.35(2) : 196-202, 2000 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2000
Keywords
Hepatocellular carcinoma ; Hepatitis B virus ; young age ; Screening test
Abstract
Background/Aims: Most of hepatocellular carcinoma (HCC) develops during 6th and 7th decade, and HCC development at the age under 40 is unusual. To understand the usefulness of HCC screening test and to determine guidelines for the treatment in young age patients group, we compared the clinical characteristics and prognosis of the patients with HCC retrospectively between patients under 40 and patients over 40. Methods: A retrospective analysis of the clinical data and survival rate was performed for 603 patients who were admitted to Yonsei medical center from April 1991 through April 1994. We divided the patients into two groups: young age group (≤40 years) and senior group ( 40 years). Results: Among 603 patients examined, the number of patients in young age group was 67 (11.1%) and their male to female ratio was 10.2:1. Most patients (93%) had subjective symptoms at admission and sixty-four (95.5%) of 67 young HCC patients were HBsAg-positive. However, none of them was anti-HCV-positive. Elevated serum αfetoprotein level (>400 ng/ml) was more common in the young age group (77.6%) than in the senior group (63.9%). According to the gross type, massive type was more common in the young age group (42.4% vs. 27.9%). The association of cirrhosis was less common in young age group than in the senior group (59.7% vs. 71.6%). The cumulative survival rate of 1, 2, and 3 year in the young age group was 35.4%, 29.2%, and 16.6%, respectively. Such rates were similar to those of the senior group. Conclusions: HCC development in young age group was closely related with hepatitis B viral infection and HCC screening test may be needed in young male patients with chronic hepatitis B. (Kor J Gastroenterol 2000;35:196 - 202)
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Yong Han(백용한)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172188
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