Cytomegalovirus (CMV) infections are commonly reported in immunocompromised hosts and ulcers of the alimentary tract are frequently observed in patients with systemic CMV infection. However, many reports show that CMV infection can produce localized ulcerations in the esophagus, stomach, small intestine, and colon of immunocompetent individuals. The common site involved by CMV infection in the gastrointestinal (GI) tract is the colon, which is followed by upper GI tract. The case in which CMV infection involves the small intestine is rare. Although GI bleeding is one of the major symptoms of patients with CMV infections in the GI tract, lower GI bleeding due to CMV ileal ulcers in immunocompetent patients has not been reported yet. Recently, we experienced a case of lower GI bleeding due to CMV ileal ulcers in a healthy 57-year-old man. This case suggests that small intestinal ulcers by CMV infection may be considered to cause lower GI bleeding even in immunocompetent hosts.