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자궁내막암에서의 E-cadherin 및 α-, β-, γ-catenin 단백의 발현

Other Titles
 Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial 
 최은경  ;  김영태  ;  양우익  ;  김재욱 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.43(4) : 625-634, 2000 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
Issue Date
α- ; β- ; γ-catenin ; 예후인자 ; Endometrial carcinoma ; Prognostic factors ; Prognostic factors ( E-cadherin
Objectives : E-cadherin is a transmembrane protein that is one of the key players involved in cell to cell adhesion. Loss of E-cadherin expression is suggested to promote tumor invasion and distant metastasis in tumor development. Recently, it has been proposed E-cadherin function requires its linkage to the cytoskeleton through catenins. So defects in catenins may cause defective E-cadherin function and promote tumor invasion. We intend to evaluate the expression of E-cadherin and α-, β-, γ- catenin in tissues of human endometrial carcinoma to analyze the patterns of cell adhesion molecules' expression in endometrial carcinoma and to investigate the relationship between status of cell adhesion molecules and various clinicopathological factors. Materials and methods : The present study investigated the immunohistochemical expression of E-cadherin and α-, β-, γ- catenin in 33 paraffin embedded formalin fixed tissues of endometrial carcinomas. Results : Aberrant E-cadherin, α-, β-, γ- catenin expression was observed in 33.3(11 of 33), 27.3(9 of 33), 18.2 (6 of 33), and 51.5(17 of 33) % of the specimens, respectively. Statistically significant correlation was found between aberrant expression of E-cadherin and lymph node metastasis and cell types other than endometrioid adenocarcinoma. Aberrant pattern of γ- catenin expression also correlated with deep myometrial invasion. But α-, β- catenin expression were not correlated with any clinicopathological parameters. Using Kaplan-Meier curves, abnormal expression of E-cadherin correlated closely with poor survival (p<0.05). Conclusion : We revealed aberrant expression of these cell adhesion molecules in part of patients with endometrial carcinoma. Aberrant expression of E-cadherin was correlated with lymph node metastasis and cell types other than endometrioid adenocarcinoma and aberrant expression of γ-catenin was related with deep myometrial invasion.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
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