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다낭성 난포 증후군에서 혈장 렙틴 수치: 인슐린 저항성과의 관계

Other Titles
 Plasma leptin levels in polycystic ovary syndrome: in relation to insulin resistance 
 김진영  ;  박기현  ;  이상준  ;  조은미  ;  김정연  ;  배상욱  ;  이병석  ;  조동제  ;  송찬호  ;  김재욱  ;  송영득 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.43(4) : 675-681, 2000 
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) 
Issue Date
Leptin ; PCOS ; Insulin resistance
OBJECTIVES: To investigate the leptin levels and their relations with BMI, body fat, basal insulin and insulin resistance (sensitivity) in polycystic ovary syndrome(PCOS). And to determine whether acute hyperinsulinemia affects the leptin levels. Materials and methods: In 15 PCOS patients and body fat-matched 22 normal controls, plasma leptin levels and fasting basal insulin levels were measured. The correlations between leptin and BMI, body fat and basal insulin levels were analysed for PCOS and controls. In addition, the insulin sensitivity was measured by 2-hour euglycemic hyperinsulinemic clamp test and the relation with leptin levels was analysed for the PCOS. RESULTS: Basal leptin levels were higher in PCOS group (12.74+/-0.65ng/ml) than control group (9.81+/-0.72ng/ml). In control group, basal leptin levels were positively correlated with BMI (r2=0.45, p<0.05), body fat (r2=0.23, p<0.05) and basal insulin (r2=0.17, p<0.05). But, in PCOS group, only BMI showed a significant correlation with leptin levels (r2=0.32, p<0.05), but body fat, insulin and insulin sensitivity index were not associated with the leptin levels. After 2 hours of insulin clamp in PCOS group, the leptin levels did not show a significant change. CONCLUSION: It appears that the leptin levels in PCOS are higher than controls and are not associated with body fat, basal insulin and insulin resistance in contrast to controls. The leptin levels did not increase as expected according to the increase of body fat and insulin. These results suggest that the regulation mechanism of leptin may be a complicated process involving body fat, insulin and insulin resistance, and the insulin resistance of adipocyte may negatively influence to the stimulatory effect of insulin and adiposity on the leptin secretion in PCOS. Acute hyperinsulinemia does not affect the leptin levels.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
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